Glp1-mediated gut–brain neural circuit controls appetite suppression

Access through your institution Buy or subscribe An inter-organ neural circuit involving enteric neurons in the small intestine and stomach that ultimately connect to the brain controls

appetite suppression, according to new research in mice. The sensorimotor circuit was delineated in a series of experiments and was mediated by local actions of the gut peptide glucagon-like

peptide 1 (GLP1). “GLP1, rather than acting as a circulating endocrine hormone, signals through a neuronal network that involves lower gut enteric neurons all the way to the appetite

centres in the brain that control the cranial muscles that execute feeding,” explains author Ivan de Araujo. Using a variety of techniques across their experiments, including optogenetics,

electrophysiology and animal models, the investigators first found that endogenous GLP1 (released by ileal L cells) acts on ileal enteric neurons, causing marked gastric distension and

appetite suppression in mice. Importantly, myenteric intestinofugal neurons (projecting to abdominal sympathetic ganglia) mediated the gastric and anorectic effects of GLP1 in the mice.

Ablation of ileal intestinofugal neurons eliminated the GLP1 effects (gastric, anorectic, coeliac ganglia and brain effects), whereas chemical activation of these specific neurons mimicked

the neuronal and appetite-reducing effects of GLP1. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54

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Zhang, T. et al. An inter-organ neural circuit for appetite suppression. _Cell_ https://doi.org/10.1016/j.cell.2022.05.007 (2022) Article  PubMed  PubMed Central  Google Scholar  Download

references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Gastroenterology & Hepatology http://www.nature.com/nrgastro/ Katrina Ray Authors * Katrina Ray View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Katrina Ray. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Ray, K. GLP1-mediated gut–brain neural circuit controls appetite suppression. _Nat Rev Gastroenterol Hepatol_ 19, 486 (2022).

https://doi.org/10.1038/s41575-022-00648-0 Download citation * Published: 21 June 2022 * Issue Date: August 2022 * DOI: https://doi.org/10.1038/s41575-022-00648-0 SHARE THIS ARTICLE Anyone

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