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Genetic screens uncover a bioactivation pathway for Lasonolide A involving enrichment in lipid droplets and cleavage into a cytotoxic, soluble metabolite by a lipid droplet-associated serine
hydrolase. These findings identify enzymatically regulated phase partitioning as a drug activation mechanism. Access through your institution Buy or subscribe This is a preview of
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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Walther, T. C., Chung, J. & Farese, R. V. Jr. _Annu. Rev. Cell Dev. Biol._ 33,
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Article CAS Google Scholar * Greenwood, D. J. et al. _Science_ 364, 1279–1282 (2019). Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA Zhipeng Li, Siti Nur Sarah Morris & James A. Olzmann * Chan Zuckerberg Biohub,
San Francisco, CA, USA James A. Olzmann Authors * Zhipeng Li View author publications You can also search for this author inPubMed Google Scholar * Siti Nur Sarah Morris View author
publications You can also search for this author inPubMed Google Scholar * James A. Olzmann View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING
AUTHOR Correspondence to James A. Olzmann. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Li, Z., Morris, S.N.S. & Olzmann, J.A. Going through a phase. _Nat Chem Biol_ 16, 111–112 (2020). https://doi.org/10.1038/s41589-019-0448-6 Download citation *
Published: 13 January 2020 * Issue Date: February 2020 * DOI: https://doi.org/10.1038/s41589-019-0448-6 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this
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