Car t cells drive out b cells in sle

Access through your institution Buy or subscribe B cell depletion is an effective approach for the treatment of several diseases, including rheumatoid arthritis (RA); however, despite

showing initial promise in the treatment of systemic lupus erythematosus (SLE), the B cell depleting anti-CD20 antibody rituximab did not reach the clinical endpoints in two large phase III

clinical trials. Almost a decade later, a promising new approach to B cell depletion in SLE is emerging: CD19-targeted chimeric antigen receptor (CAR) T cell therapy. Unlike a standard CAR T

cell approach, the researchers used purified CD8+ T cells to avoid any potential disease-promoting effects that might come from using CD4+ T cells. As a second generation CAR, the CD3ζ C

terminus had been modified to dampen its activity and prevent T cell exhaustion (increasing the persistence of this therapy). This is a preview of subscription content, access via your

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Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional

subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Kansal, R. et al. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective

treatment for murine lupus. _Sci. Transl. Med._ 11, eaav1648 (2019) Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology

http://www.nature.com/nrrheum/ Jessica McHugh Authors * Jessica McHugh View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Jessica McHugh. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McHugh, J. CAR T cells drive out B cells in SLE. _Nat Rev Rheumatol_

15, 249 (2019). https://doi.org/10.1038/s41584-019-0214-x Download citation * Published: 04 April 2019 * Issue Date: May 2019 * DOI: https://doi.org/10.1038/s41584-019-0214-x SHARE THIS

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