The association between carbon dioxide, cerebral blood flow, and autoregulation in the premature infant

ABSTRACT OBJECTIVE Evaluate the association between carbon dioxide (pCO2), cerebral blood flow (CBF), and cerebral autoregulation (CA) in preterm infants. STUDY DESIGN Cerebral saturations

(rScO2, surrogate for CBF using NIRS) and mean arterial blood pressure (MAP) monitored for 96 h in infants <29 weeks gestation. Relationship between rScO2, the rScO2-MAP correlation (CA

analysis) and pCO2 category assessed by mixed effects modeling. RESULTS Median pCO2 differed by postnatal day (_p_ < 0.0001)—pCO2 increased between day 1 and 2, and low variability seen

on day 4. A 5% increase in rScO2 was noted when pCO2 was >55 mmHg on each postnatal day (_p_ < 0.001). No association observed between the overall rScO2-MAP correlation and pCO2. On

day 1 only, the correlation coefficient decreased from 0.26 to −0.09 as pCO2 category increased (_p_ = 0.02). CONCLUSIONS CBF increased above a pCO2 threshold of 55 mmHg, but overall, no

association between pCO2 and CA was noted. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CEREBRAL OXYGEN SATURATION AND AUTOREGULATION DURING HYPOTENSION IN EXTREMELY PRETERM INFANTS

Article 20 April 2021 ASSOCIATION BETWEEN EARLY CEREBRAL OXYGENATION AND NEURODEVELOPMENTAL IMPAIRMENT OR DEATH IN PREMATURE INFANTS Article 15 February 2021 LONGITUDINAL PILOT STUDY OF

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for the germinal matrix. Front Neurol. 2018;9:812. http://www.ncbi.nlm.nih.gov/pubmed/30356709. Article  Google Scholar  Download references FUNDING This study is funded by the Mentored

Population and Clinical Research Program of the American Heart Association, Award #14CRP18140003 to SBH. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of

Maryland Baltimore, School of Medicine, Baltimore, MD, USA Suma Bhat Hoffman, Anisa Lakhani & Rose Marie Viscardi Authors * Suma Bhat Hoffman View author publications You can also

search for this author inPubMed Google Scholar * Anisa Lakhani View author publications You can also search for this author inPubMed Google Scholar * Rose Marie Viscardi View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Suma Bhat Hoffman. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors

declare that they have no conflict of interest. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and

institutional affiliations. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hoffman, S.B., Lakhani, A. & Viscardi, R.M. The association between

carbon dioxide, cerebral blood flow, and autoregulation in the premature infant. _J Perinatol_ 41, 324–329 (2021). https://doi.org/10.1038/s41372-020-00835-4 Download citation * Received: 06

April 2020 * Revised: 24 August 2020 * Accepted: 18 September 2020 * Published: 08 October 2020 * Issue Date: February 2021 * DOI: https://doi.org/10.1038/s41372-020-00835-4 SHARE THIS

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