First-line parp inhibition in ovarian cancer — standard of care for all?

In 2018, the SOLO1 trial set a new standard of care with maintenance olaparib substantially extending progression-free survival (PFS) in women with newly-diagnosed _BRCA1/2_-mutated

advanced-stage ovarian cancer. Herein, we summarize trials of first-line poly(ADP-ribose) polymerase (PARP) inhibition beyond _BRCA1/2_ mutations, including combination strategies, and

discuss the optimum use of PARP inhibition in advanced-stage ovarian cancer. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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Google Scholar  Download references ACKNOWLEDGEMENTS The authors acknowledge the National Institute for Health Research, Royal Marsden and ICR Biomedical Research Centre for Cancer. The work

of C.J.L. is funded by Breast Cancer Now as part of Programme Funding to the Breast Cancer Now Toby Robins Research Centre (CTR-Q4-Y2) and by a Cancer Research UK Programme Grant

(CRUK/A14276). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK Susana N. Banerjee * Breast Cancer Now Toby

Robins Research Centre and Cancer Research UK Gene Function Laboratory, Institute of Cancer Research, London, UK Christopher J. Lord Authors * Susana N. Banerjee View author publications You

can also search for this author inPubMed Google Scholar * Christopher J. Lord View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Susana N. Banerjee. ETHICS DECLARATIONS COMPETING INTERESTS S.B. has received honoraria as an advisory board member and/or giving lectures for AstraZeneca, Clovis, Genmabs,

Merck Serono, Pharmamar, Roche, Seattle Genetics and Tesaro/GSK. C.J.L. has received research funding from Artios, AstraZeneca and Merck KGaA; has received honoraria as a consultant or

senior advisory board for Artios, AstraZeneca, Gerson Lehrman Group, Merck KGaA, Ono Pharma, Sun Pharma, Syncona, Tango, Third Rock and Vertex; owns stock in Ovibio and Tango; and is a named

inventor on patents describing the use of DNA repair inhibitors and stands to gain from the development as part of the ICR Rewards to Inventors scheme. SUPPLEMENTARY INFORMATION

SUPPLEMENTARY TABLE 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Banerjee, S.N., Lord, C.J. First-line PARP inhibition in ovarian cancer — standard

of care for all?. _Nat Rev Clin Oncol_ 17, 136–137 (2020). https://doi.org/10.1038/s41571-020-0335-9 Download citation * Published: 12 February 2020 * Issue Date: March 2020 * DOI:

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