Arousal response from sleep to tracheal obstruction in lambs during postnatal maturation


Play all audios:

ABSTRACT ABSTRACT: Experiments were carried out to investigate the arousal response from sleep to tracheal obstruction in lambs during postnatal maturation. Ten fetal sheep were instrumented


with electrodes for sleep staging and a tracheotomy was done. After spontaneous vaginal delivery, serial experiments were carried out on the lambs at five postnatal ages: 18–48 h and 4, 6,


11, and 18 d. During an experiment, a 5F balloon-tipped catheter was inserted into the tracheostomy tube so that tracheal obstruction could be produced by inflating the balloon. Measurements


were made in quiet sleep and active sleep during control periods of tidal respiration and during experimental periods of tracheal obstruction. Neither sleep state nor age influenced control


arterial Hb oxygen saturation (Sao2). Sao2 decreased significantly before arousal during tracheal obstruction in quiet sleep at 18–48 h and in active sleep at all ages. The SaO2 at arousal


was always lower in active sleep than in quiet sleep. overall, however, there were no significant effects of age on the change in SaO2 before arousal in either quiet sleep or active sleep.


The time to arousal during tracheal obstruction increased between 18–48 h and 6 d of postnatal life in active sleep but not in quiet sleep. our data provide evidence that the arousal


response to tracheal obstruction is functional by 18 h of postnatal life in lambs. The increase in time to arousal after tracheal obstruction in active sleep most likely results from


state-specific changes in the factors governing oxygen supply and demand. SIMILAR CONTENT BEING VIEWED BY OTHERS SPONTANEOUS AND APNEA AROUSALS FROM SLEEP IN PRETERM INFANTS Article 18 July


2020 THE IMPACT OF SLEEP IN HIGH-RISK INFANTS Article Open access 10 April 2025 CAFFEINE IS A RESPIRATORY STIMULANT WITHOUT EFFECT ON SLEEP IN THE SHORT-TERM IN LATE-PRETERM INFANTS Article


Open access 30 October 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medical Physiology, University of Calgary, Calgary, T2N 4N1, Alberta, Canada Teresa L


Davidson & James E Fewell Authors * Teresa L Davidson View author publications You can also search for this author inPubMed Google Scholar * James E Fewell View author publications You


can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Davidson, T., Fewell, J. Arousal Response from


Sleep to Tracheal obstruction in Lambs during Postnatal Maturation. _Pediatr Res_ 36, 501–505 (1994). https://doi.org/10.1203/00006450-199410000-00016 Download citation * Received: 12 April


1993 * Accepted: 27 March 1994 * Issue Date: 01 October 1994 * DOI: https://doi.org/10.1203/00006450-199410000-00016 SHARE THIS ARTICLE Anyone you share the following link with will be able


to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing


initiative