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The debate over whether to agonize or antagonize GIPR signalling has divided the obesity drug design field. Studies from Gutgesell et al. and Liu et al. represent important first steps
towards disentangling divergent neural networks that explain the success of both strategies for promoting weight loss. Access through your institution Buy or subscribe This is a preview of
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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Véniant, M. M. et al. _Nat. Metab._ 6, 290–303 (2024). Article
PubMed PubMed Central Google Scholar * Jastreboff, A. M. et al. _N. Engl. J. Med._ 387, 205–216 (2022). Article CAS PubMed Google Scholar * Gutgesell, R. M. et al. _Nat. Metab_.
https://doi.org/10.1038/s42255-025-01294-x (2025). * Liu, C. M. et al. _Nat. Metab._ https://doi.org/10.1038/s42255-025-01295-w (2025). Article PubMed PubMed Central Google Scholar *
Liskiewicz, A. et al. _Nat. Metab._ 5, 2075–2085 (2023). Article CAS PubMed PubMed Central Google Scholar * Mroz, P. A. et al. _Mol. Metab._ 20, 51–62 (2019). Article CAS PubMed
Google Scholar * Wean, J. et al. _Mol. Metab._ 95, 102074 (2024). Article PubMed PubMed Central Google Scholar * Zhang, C., Vincelette, L. K., Reimann, F. & Liberles, S. _Cell Rep._
39, 110953 (2022). Article CAS PubMed PubMed Central Google Scholar * Smith, C. et al. _Appetite_ 174, 106022 (2022). Article PubMed PubMed Central Google Scholar * Ludwig, M. Q.,
Todorov, P. V., Egerod, K. L., Olson, D. P. & Pers, T. H. _Diabetes_ 70, 1945–1955 (2021). Article CAS PubMed PubMed Central Google Scholar Download references ACKNOWLEDGEMENTS
A.E.A is supported by the EFSD (European Foundation for the Study of Diabetes)/Novo Nordisk Foundation Future Leaders Award (NNF21SA0072744). For the purpose of open access, the author has
applied a Creative Commons Attribution (CC BY) license to any author accepted manuscript version arising from this submission. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Centre for
Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK Alice E. Adriaenssens Authors * Alice E.
Adriaenssens View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Alice E. Adriaenssens. ETHICS DECLARATIONS COMPETING
INTERESTS The author declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Adriaenssens, A.E. Unravelling the GIPR agonist
versus antagonist paradox. _Nat Metab_ (2025). https://doi.org/10.1038/s42255-025-01299-6 Download citation * Published: 29 April 2025 * DOI: https://doi.org/10.1038/s42255-025-01299-6 SHARE
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