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Access through your institution Buy or subscribe Gliomas and breast-cancer-derived brain metastases (B2BMs) are types of brain tumour associated with poor prognosis. Whether and how the
cells in these tumours interact synaptically with brain cells has not been clear. Three papers in _Nature_ now detail synaptic interactions between neurons and glioma or B2BM cells that seem
to promote tumour growth. Both groups recorded excitatory postsynaptic potentials (EPSCs) in glioma cells in tumour samples from human patients or in slices of tumour-xenografted mouse
brains. These EPSCs depended on neuronal activity, suggesting that the observed neurogliomal synapses were functional. Moreover, in line with the gene-expression data, the EPSCs depended on
Ca2+-permeable AMPARs. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio
journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $189.00 per
year only $15.75 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated
during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLES * Venkatesh, H. S. et
al. Electrical and synaptic integration of glioma into neural circuits. _Nature_ 573, 539–545 (2019) Article CAS Google Scholar * Venkataramani, V. et al. Glutamatergic synaptic input to
glioma cells drives brain tumour progression. _Nature_ 573, 532–538 (2019) Article CAS Google Scholar * Zeng, Q. et al. Synaptic proximity enables NMDAR signalling to promote brain
metastasis. _Nature_ 573, 526–531 (2019) Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Neuroscience
http://www.nature.com/nrn/ Natasha Bray Authors * Natasha Bray View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to
Natasha Bray. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bray, N. Contact with the enemy. _Nat Rev Neurosci_ 20, 716–717 (2019).
https://doi.org/10.1038/s41583-019-0230-5 Download citation * Published: 01 October 2019 * Issue Date: December 2019 * DOI: https://doi.org/10.1038/s41583-019-0230-5 SHARE THIS ARTICLE
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