Obesity is transferable through the gut microbiota

Access through your institution Buy or subscribe Since the discovery in the 1600s of microscopic organisms, scientists have investigated the relationship between our health and the microbes

that surround and inhabit us. Nowadays, we acknowledge that some microbes are inherently pathogenic, but also that others live mutualistically on and within our bodies and contribute to

maintaining our well-being. Yet, one prominent challenge remains: to convincingly move past mere association and prove causality. Our microbiotas have been increasingly associated with

various diseases, including obesity, but demonstrating a relationship between cause and effect is essential — particularly for the development of targeted therapeutics. Ten years ago, a gold

standard for translatability within the field of microbiota–metabolism research was set. Through the meticulous use of key methodologies, Ridaura and colleagues reproducibly demonstrated

that microbial communities within our gut can directly influence host metabolism and obesity. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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support REFERENCES ORIGINAL ARTICLE * Ridaura, V. K. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. _Science_ 341, 1241214 (2013) Article  PubMed 

Google Scholar  RELATED ARTICLES * Larsen, I. S. et al. Experimental diets dictate the metabolic benefits of probiotics in obesity. _Gut Microbes_ 15, 2192547 (2023) Article  PubMed  PubMed

Central  Google Scholar  * Wastyk, H. C. et al. Randomized controlled trial demonstrates response to a probiotic intervention for metabolic syndrome that may correspond to diet. _Gut

Microbes_ 15, 2178794 (2023) Article  PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biomedical Sciences, University

of Copenhagen, Copenhagen, Denmark Béatrice S.-Y. Choi & Sune K. Yang-Jensen Authors * Béatrice S.-Y. Choi View author publications You can also search for this author inPubMed Google

Scholar * Sune K. Yang-Jensen View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Sune K. Yang-Jensen. ETHICS

DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Choi, B.SY., Yang-Jensen,

S.K. Obesity is transferable through the gut microbiota. _Nat Rev Endocrinol_ 19, 687 (2023). https://doi.org/10.1038/s41574-023-00907-3 Download citation * Published: 28 September 2023 *

Issue Date: December 2023 * DOI: https://doi.org/10.1038/s41574-023-00907-3 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

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