Bat is involved in control of satiation

Access through your institution Buy or subscribe Brown adipose tissue (BAT) has an important function in the control of satiation via prandial thermogenesis and represents an interesting

potential target for tackling obesity, according to a new paper. First, the researchers analysed transcriptome data obtained from interscapular BAT (iBAT) of mice to screen for abundantly

expressed gut hormone receptors. “We reasoned that corresponding gut hormones secreted into circulation during a meal may activate brown fat through these receptors,” notes Klingenspor.

Transcript abundance of the secretin receptor gene (_Sctr_) was much higher than that of other gut hormone receptor genes. This is a preview of subscription content, access via your

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subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Li, Y. et al. Secretin-activated brown fat mediates prandial thermogenesis to induce satiation. _Cell_

https://doi.org/10.1016/j.cell.2018.10.016 (2018) Article  PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews

Endocrinology http://www.nature.com/nrendo/ Rebecca Kelsey Authors * Rebecca Kelsey View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Rebecca Kelsey. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kelsey, R. BAT is involved in control of satiation. _Nat Rev

Endocrinol_ 15, 1 (2019). https://doi.org/10.1038/s41574-018-0136-8 Download citation * Published: 28 November 2018 * Issue Date: January 2019 * DOI:

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