Neural regulation of muscarinic receptors in chick expansor secundariorum muscle

ABSTRACT We have recently observed the loss of muscarinic receptors from a smooth muscle of the chicken wing, the expansor secundariorum, during post-hatch development1. The nerve supplying

the muscle has been shown to consist mainly of sympathetic fibres that, when stimulated, cause muscle contraction by the release of noradrenaline and subsequent activation of

_α_-adrenoreceptors. Although no acetylcholine release has been detected in isolated nerve–muscle preparations2, the presence of a cholinergic input has not been clearly excluded. Kuromi and

Hagihara2 observed that atropine was ineffective in blocking the nerve stimulation-induced contraction of the muscle, whereas phentolamine partly and guanethedine totally abolished the

contraction. We have now examined the effect of denervation of the muscle 1 day after hatch on the binding of 3H-quinuclidinyl benzilate (3H-QNB), a radioligand for muscarinic receptors3,4.

Our results indicate that the normal loss of muscarinic receptors from the expansor secundariorum is prevented by denervation. This observation is important as it demonstrates the regulation

of a receptor population by a nerve supply that apparently does not release the corresponding transmitter. Access through your institution Buy or subscribe This is a preview of subscription

content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue

Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL

ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS STRUCTURAL MECHANISM OF MUSCLE NICOTINIC

RECEPTOR DESENSITIZATION AND BLOCK BY CURARE Article 17 March 2022 REEVALUATION OF MOTONEURON MORPHOLOGY: DIVERSITY AND REGULARITY AMONG MOTONEURONS INNERVATING DIFFERENT ARM MUSCLES ALONG A

PROXIMAL–DISTAL AXIS Article Open access 04 August 2020 STRUCTURAL SWITCH IN ACETYLCHOLINE RECEPTORS IN DEVELOPING MUSCLE Article 31 July 2024 REFERENCES * Crouch, M. F., Morris, C. P.,

Cheah, T. B. & Rush, R. A. _Brain Res._ 232, 212–215 (1982). Article  CAS  Google Scholar  * Kuromi, H. _Eur. J. Pharmac._ 51, 285–289 (1978). Article  CAS  Google Scholar  * Yamamura,

H. I. & Snyder, S. H. _Proc. natn. Acad. Sci. U.S.A._ 71, 1725–1729 (1974). Article  ADS  CAS  Google Scholar  * Yamamura, H. I. & Snyder, S. H. _Moled. Pharmac._ 10, 861–867 (1974).

CAS  Google Scholar  * Campbell, G. R., Allan, B. I. & Gannon, B. J. _J. Cell Tissue Res._ 176, 143–156 (1977). CAS  Google Scholar  * Axelsson, S., Bjorkland, A., Falck, B., Lindwall,

O. & Svensson, L. A. _Acta physiol. scand._ 87, 57–62 (1973). Article  CAS  Google Scholar  * Hulme, E. C., Birdsall, N. J. M., Burgen, A. S. V. & Mehta, P. _Molec. Pharmac._ 14,

737–750 (1978). CAS  Google Scholar  * Birt, D. R. _Brain Res._ 143, 573–579 (1978). Article  Google Scholar  * Guth, L. _Physiol. Rev._ 48, 645–687 (1969). Article  Google Scholar  *

Harris, A. J. in _Physiology of Peripheral Nerve Disease_ (ed. Sumner, A. J.) 195–220 (Saunders, London, 1980). Google Scholar  * Bennett, T. E. & Malmfors, T. _Z. Zellforsch._ 106,

22–50 (1970). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Centre for Neuroscience and Departments of Human Physiology and Human

Morphology, The Flinders University of South Australia, Bedford Park, South Australia, 5042, Australia R. A. Rush, M. F. Crouch, C. P. Morris & B. J. Gannon Authors * R. A. Rush View

author publications You can also search for this author inPubMed Google Scholar * M. F. Crouch View author publications You can also search for this author inPubMed Google Scholar * C. P.

Morris View author publications You can also search for this author inPubMed Google Scholar * B. J. Gannon View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rush, R., Crouch, M., Morris, C. _et al._ Neural regulation of muscarinic receptors in chick

expansor secundariorum muscle. _Nature_ 296, 569–570 (1982). https://doi.org/10.1038/296569a0 Download citation * Received: 09 October 1981 * Accepted: 15 February 1982 * Published: 01 April

1982 * Issue Date: 08 April 1982 * DOI: https://doi.org/10.1038/296569a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative