Retraction note: systems engineering of escherichia coli for high-level glutarate production from glucose

Retraction to: _Nature Communications_ https://doi.org/10.1038/s41467-024-45448-z, published online 03 February 2024 The Editors have retracted this article at the request of the authors.

After publication, the authors were informed of concerns regarding the activity of the final enzyme of the newly constructed pathway for glutarate production from glucose. The enzyme

(_Kp_ALDH) was derived from _Klebsiella pneumoniae_ and initially considered to have the aldehyde dehydrogenase activity. However, based on sequence comparison and computational modeling of

structure and reaction mechanism, _Kp_ALDH is closely related to macrolide phosphotransferase rather than aldehyde dehydrogenase. As a result, the authors repeated experiments for the

enzymatic activity of _Kp_ALDH and concluded that _Kp_ALDH cannot catalyze the synthesis of glutarate from glutaraldehyde, as had been reported in this paper. In addition, the authors found

that the product of their fermentation experiment was not glutarate after optimizing the HPLC detection method. As these were the key findings of this article, the authors consider that the

conclusions of this work are unsupported. The authors would like to apologize for any inconvenience caused to the readers of the journal. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * School

of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi, 214122, China Zhilan Zhang, Ruyin Chu, Wanqing Wei, Xiulai Chen, Liming

Liu & Cong Gao * School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China Wei Song & Jing Wu * School of Food Science and Pharmaceutical Engineering,

Nanjing Normal University, Nanjing, 210000, China Chao Ye Authors * Zhilan Zhang View author publications You can also search for this author inPubMed Google Scholar * Ruyin Chu View author

publications You can also search for this author inPubMed Google Scholar * Wanqing Wei View author publications You can also search for this author inPubMed Google Scholar * Wei Song View

author publications You can also search for this author inPubMed Google Scholar * Chao Ye View author publications You can also search for this author inPubMed Google Scholar * Xiulai Chen

View author publications You can also search for this author inPubMed Google Scholar * Jing Wu View author publications You can also search for this author inPubMed Google Scholar * Liming

Liu View author publications You can also search for this author inPubMed Google Scholar * Cong Gao View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Cong Gao. RIGHTS AND PERMISSIONS OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License, which permits

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ARTICLE CITE THIS ARTICLE Zhang, Z., Chu, R., Wei, W. _et al._ Retraction Note: Systems engineering of _Escherichia coli_ for high-level glutarate production from glucose. _Nat Commun_ 15,

8742 (2024). https://doi.org/10.1038/s41467-024-53070-2 Download citation * Published: 09 October 2024 * DOI: https://doi.org/10.1038/s41467-024-53070-2 SHARE THIS ARTICLE Anyone you share

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