Evaluation of a-ring hydroxymethylene-amino- triterpenoids as inhibitors of sars-cov-2 spike pseudovirus and influenza h1n1

ABSTRACT A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. The synthesized compounds were tested for their potential

inhibition of SARS-CoV-2 pseudovirus in BHK-21-hACE2 cells and influenza A/PuertoRico/8/34 (H1N1) virus in MDCK cell culture. Compounds 6, 8 and 19 showed significant anti-SARS-CoV-2

pseudovirus activity with EC50 value of 3.20-11.13 µM, which is comparable to the positive control amodiaquine (EC50 3.17 µM). Among them, 28-_O_-imidazolyl-azepano-betulin 6 and

C3-hydroxymethylene-amino-glycyrrhetol-11,13-diene 19 were identified as the lead compounds with SI values of 7 and 10. The binding mode of compound 6 into the RBD domain of SARS-CoV-2 spike

glycoprotein (PDB code: 7DK3) by docking and molecular dynamics simulation was investigated. Access through your institution Buy or subscribe This is a preview of subscription content,

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COMPUTATIONAL INVESTIGATIONS OF SCHIFF’S BASES OF 1,3-DIPHENYL UREA DERIVATIVES AGAINST SARS-COV-2 SPIKE PROTEIN Article Open access 01 June 2024 DISCOVERING NATURAL PRODUCTS AS POTENTIAL

INHIBITORS OF SARS-COV-2 SPIKE PROTEINS Article Open access 02 January 2025 IDENTIFICATION OF ANTIVIRAL PHYTOCHEMICALS AS A POTENTIAL SARS-COV-2 MAIN PROTEASE (MPRO) INHIBITOR USING DOCKING

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AFFILIATIONS * Ufa Institute of Chemistry UFRC RAS, pr. Oktyabrya 71, 450054, Ufa, Russia Oxana Kazakova, Elena Tretyakova & Irina Smirnova * State Key Laboratory of Natural and

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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kazakova, O., Ma, X., Tretyakova, E. _et al._ Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike

pseudovirus and influenza H1N1. _J Antibiot_ 77, 39–49 (2024). https://doi.org/10.1038/s41429-023-00677-0 Download citation * Received: 13 March 2023 * Revised: 24 October 2023 * Accepted:

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