Age-related changes in humoral and cell- mediated immunity in down syndrome children living at home

ABSTRACT ABSTRACT. Abnormalities of humoral and cell-mediated immunity have been described in Down syndrome but reported findings have been inconsistent. Confounding factors have included

age, institutional _versus_ home life, hepatitis B antigenemia, and zinc deficiency. To clarify this problem, we studied 64 children with Down syndrome (DS) compared with an age-matched

control group. All children had always lived at home. All the DS children were negative for hepatitis B surface antigen. Serum zinc concentration in the DS group was on average 12 μg/dl

lower than age-matched control children. They also had significantly lower levels of immunoglobulin M, total lymphocyte count, T and B lymphocytes, and T helper and suppressor cells. _In

vitro_ lymphocyte response to phytohemagglutinin and concanavalin A was significantly reduced at all ages in the DS group. Lymphocyte response to pokeweed mitogen increased with age in

control children but decreased in the DS children. By 18 yr, the mean response for DS was 60000 cpm lower than controls. The DS group had significantly higher concentrations of

immunoglobulins A and G than controls and the difference increased with age. Complement fractions C3 and C4 were also higher in the DS group at all ages. The number of HNK-1 positive cells

was higher in the DS group than controls at all ages. When hepatitis and institutionalization are excluded as confounding factors, DS children still differ in both humoral and cell-mediated

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ANTI-INFLAMMATORY SERUM MARKER GDF-15 WITH SERUM IGA AND IGG IN APPARENTLY HEALTHY CHILDREN Article Open access 14 September 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Departments of Pathology, Pediatrics and Health Care and Epidemiology of the University of British Columbia, and British Columbia Children's Hospital, Vancouver, British Columbia,

Canada Gillian Lockitch, V K Singh, M L Puterman, W J Godolphin, S Sheps, A J Tingle, F Wong & G Quigley Authors * Gillian Lockitch View author publications You can also search for this

author inPubMed Google Scholar * V K Singh View author publications You can also search for this author inPubMed Google Scholar * M L Puterman View author publications You can also search

for this author inPubMed Google Scholar * W J Godolphin View author publications You can also search for this author inPubMed Google Scholar * S Sheps View author publications You can also

search for this author inPubMed Google Scholar * A J Tingle View author publications You can also search for this author inPubMed Google Scholar * F Wong View author publications You can

also search for this author inPubMed Google Scholar * G Quigley View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lockitch, G., Singh, V., Puterman, M. _et al._ Age-Related Changes in Humoral and Cell- Mediated Immunity in Down Syndrome Children Living at

Home. _Pediatr Res_ 22, 536–540 (1987). https://doi.org/10.1203/00006450-198711000-00013 Download citation * Received: 13 January 1987 * Accepted: 24 June 1987 * Issue Date: 01 November

1987 * DOI: https://doi.org/10.1203/00006450-198711000-00013 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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