Α-antitrypsin and α1-acid glycoprotein levels in the cord blood and amniotic fluid of infants with respiratory distress syndrome

ABSTRACT Summary: α1-Antitrypsin, a proteinase inhibitor, was previously shown to be decreased in the cord blood and elevated in the amniotic fluid of infants with RDS. The low cord

α1-antitrypsin in RDS may be the result of either decreased production or increased catabolism or loss of the protein by the fetus. To determine whether there is a specific preferential

decrease in α1-antitrypsin in the cord blood of infants with RDS, we have compared the reduction in blood levels of α1-antitrypsin with that of a low molecular weight protein which has no

antiproteinase activity, α1-acid glycoprotein (mol wt = 41,000). If a molecular sieve type of leakage is basic mechanism responsible for the low α1-antitrypsin in the cord blood of infants

with RDS, then α1-acid glycoprotein might be decreased at least to a comparable degree in the cord blood. Both proteins were measured by the radial immunodiffusion method hi 36 cord blood

specimens, 13 of which had matching amniotic fluids which were also studied. There was a significant lowering of the cord blood α1-acid glycoprotein in preterm infants with RDS (12.4 ± 1.3)

compared to those without RDS (21.1 ± 4.3) (_P_ < 0.05). When the same specimens were analyzed for α1-antitrypsin, the difference between preterm infants with RDS and those without RDS

did not reach statistical significance (_P_ = 0.12). These findings support the hypothesis the serum proteins are decreased in RDS mainly because of diffuse capillary leakage. Speculation:

The results of this study suggest that _in utero_ hypoxia or other factors associated with low Apgar scores and abnormal blood gases result hi increased capillary permeability. A detectable

decrease in the concentration of one or more cord serum proteins, especially those of low molecular weight, may be a sensitive indicator of fetal distress and increased capillary

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THIOREDOXIN-1 LEVELS ARE NOT ASSOCIATED WITH BRONCHOPULMONARY DYSPLASIA AND RETINOPATHY OF PREMATURITY Article Open access 16 February 2024 IGGFC-BINDING PROTEIN IN PREGNANCIES COMPLICATED

BY SPONTANEOUS PRETERM DELIVERY: A RETROSPECTIVE COHORT STUDY Article Open access 17 March 2021 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Perinatal Medicine and

Immunology-Allergy, Department of Pediatrics, Harbor General Hospital, UCLA School of Medicine, Torrance, California, USA Sok Kyu Lee, Donald W Thibeault & Douglas C Heiner Authors * Sok

Kyu Lee View author publications You can also search for this author inPubMed Google Scholar * Donald W Thibeault View author publications You can also search for this author inPubMed 

Google Scholar * Douglas C Heiner View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Lee, S., Thibeault, D. & Heiner, D. α-Antitrypsin and α1-Acid Glycoprotein Levels in the Cord Blood and Amniotic Fluid of Infants with Respiratory Distress Syndrome.

_Pediatr Res_ 12, 775–777 (1978). https://doi.org/10.1203/00006450-197807000-00007 Download citation * Issue Date: 01 July 1978 * DOI: https://doi.org/10.1203/00006450-197807000-00007 SHARE

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * α1-Acid glycoprotein * amniotic fluid * α1-antitrypsin * blood, cord * newborn * respiratory distress

syndrome