Noninvasive detection of advanced disease using mmps

Access through your institution Buy or subscribe Matrix metalloproteinases (MMPs) are known to promote tumor development and to facilitate the spread of invasive cancers. Two recent

publications conclude that high MMP levels in the urine of patients with bladder malignancy indicate advanced disease and poorer prognosis. A team from Denmark and The Netherlands studied

the levels of MMP-9 in the urine of 188 patients diagnosed with bladder cancer. Voided samples were collected and frozen prior to surgery. A commercially available immunocapture assay kit

was used to measure MMP-9 in thawed aliquots. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal

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ORIGINAL RESEARCH PAPERS * Offersen, B. V. _ et al_. Matrix metalloproteinase-9 measured in urine from bladder cancer patients is an independent prognostic marker of poor survival. _Acta

Oncol._ doi:10.3109/0284186X.2010.509109 * Szarvas, T. _ et al_. Urinary matrix metalloproteinase-7 level is associated with the presence of metastasis in bladder cancer. _BJU Int._

doi:10.1111/j.1464-410X.2010.09625.x Download references Authors * Rebecca Drake View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Drake, R. Noninvasive detection of advanced disease using MMPs. _Nat Rev Urol_ 7, 592 (2010).

https://doi.org/10.1038/nrurol.2010.172 Download citation * Published: 10 November 2010 * Issue Date: November 2010 * DOI: https://doi.org/10.1038/nrurol.2010.172 SHARE THIS ARTICLE Anyone

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