Are acpa-positive and acpa-negative ra the same disease?

Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two

distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies. Access through your institution Buy or subscribe This is a preview of

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Syversen, S. W. _ et al_. High anti-cyclic

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arthritis. _Arthritis Rheum._ doi:10.1002/art.30233. Download references ACKNOWLEDGEMENTS The authors' work is supported by grants from the Dutch Arthritis Foundation and the European

Union (Sixth Framework Program integrated project Autocure and Seventh Framework Program integrated project Masterswitch number 223404). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands Nina A. Daha & Rene E. M. Toes Authors * Nina A. Daha View author

publications You can also search for this author inPubMed Google Scholar * Rene E. M. Toes View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to Nina A. Daha. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Daha, N., Toes, R. Are ACPA-positive and ACPA-negative RA the same disease?. _Nat Rev Rheumatol_ 7, 202–203 (2011). https://doi.org/10.1038/nrrheum.2011.28

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