Mobilizing stem cells | Nature Reviews Neuroscience

Access through your institution Buy or subscribe During development, sonic hedgehog (SHH) signalling can enhance the generation of oligodendrocyte precursor cells (OPCs), suggesting that it

might have a role in remyelination. SHH drives the expression of GLI1, thus to investigate the potential role of SHH signalling in remyelination, the authors generated transgenic mice in

which GLI1-expressing (GLI1+) NSCs and their progeny were labelled with green fluorescent protein (GFP). The animals were subjected to cuprizone- or lysophosphatidylcholine-driven

demyelination of the corpus callosum, and the fates of GLI1+ cells were tracked. GLI1+ cells were recruited to the sites of demyelination and subsequently differentiated into glia, most of

which were oligodendrocytes. The presence of GFP-labelled processes surrounding axons indicated that the newly generated cells contributed to remyelination. > in mice lacking functional 

GLI1, recruitment of NSCs to lesion sites > was greater than in control mice This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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our FAQs * Contact customer support REFERENCES * Samanta, J. et al. Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination. _Nature_

http://dx.doi.org/10.1038/nature14957, (2015) Download references Authors * Katherine Whalley View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Whalley, K. Mobilizing stem cells. _Nat Rev Neurosci_ 16, 646 (2015). https://doi.org/10.1038/nrn4052 Download

citation * Published: 20 October 2015 * Issue Date: November 2015 * DOI: https://doi.org/10.1038/nrn4052 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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