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Access through your institution Buy or subscribe KV1.3 CHANNEL GENE-TARGETED DELETION PRODUCES 'SUPER-SMELLER MICE' WITH ALTERED GLOMERULI, INTERACTING SCAFFOLD PROTEINS, AND


BIOPHYSICS. Fadool, D. A. _et al_. _Neuron_ 41, 389–404 (2004) Mice with a targeted deletion of the voltage-dependent K+ channel KV1.3 are found to have a heightened sense of smell, with a


threshold for odour detection that is 1,000- to 10,000-fold lower than the wild type. Anatomically, they have smaller olfactory glomeruli than wild-type mice, and more of them. Potassium


currents in olfactory bulb neurons from the _K__V__1.3__−/−_ mice have slower inactivation and a modified voltage dependence, and are not modulated by activators of receptor tyrosine


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Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE In Brief. _Nat Rev Neurosci_ 5, 169 (2004). https://doi.org/10.1038/nrn1355 Download citation * Issue Date: March 2004 * DOI:


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