New way out for Cryptococcus | Nature Reviews Microbiology

Access through your institution Buy or subscribe Macrophages are part of the innate immune armoury that responds to pathogen invasion. Usually, macrophages ingest and kill pathogens, but

some pathogens multiply inside the phagocyte, then exit by lysing and killing it. Two reports published in _Current Biology_ reveal a third outcome of pathogen ingestion by macrophages:

_Cryptococcus neoformans_ can replicate after phagocytosis and then exit by a novel mechanism that leaves both the macrophage and the pathogen intact. Cryptococcosis has come to prominence

owing to the ability of the causative agent, _C. neoformans_, to cause meningoencephalitis and, on rare occasions, lung disease in AIDS sufferers. Understanding the pathogenesis of _C.

neoformans_ is important not only because of its propensity to cause disease in immunocompromised individuals, but because it is a model for the switch from a benign environmental organism

to a voracious pathogen of mammals and amoebae. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this

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support ORIGINAL RESEARCH PAPER * Ma, H. et al. Expulsion of live pathogenic yeast by macrophages. _Curr. Biol._ 16, 2156–2160 (2006) Article  CAS  Google Scholar  * Alvarez, M. &

Casadevall, A. Phagosome extrusion and host-cell survival after _Cryptococcus neoformans_ phagocytosis by macrophages. _Curr. Biol._ 16, 2161–2165 (2006) Article  CAS  Google Scholar 

Download references Authors * Susan Jones View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Jones, S. New way out for _Cryptococcus_. _Nat Rev Microbiol_ 5, 3 (2007). https://doi.org/10.1038/nrmicro1583 Download citation * Issue Date: 01 January 2007 *

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