Inducing dormancy | Nature Reviews Cancer

Access through your institution Buy or subscribe To establish a suitable model, the authors crossed a mouse in which the liver activator protein (LAP) promoter drives expression of the

tetracycline transactivating protein (tTA) in liver cells, with a mouse in which MYC is under control of the tetracycline response element (which is bound by tTA) — producing the

LAP-tTA/tet-off-MYC mouse. Only mice expressing both the _Lap_ and _Myc_ transgenes and not treated with doxycycline — which also regulates tTA — expressed MYC and developed hepatocellular

carcinomas. As liver tumours are usually refractory to therapy, the authors expected that inactivation of MYC in the mice with established liver tumours would be ineffective in causing

tumour regression. However, this was not the case, 50 transgenic mice moribund with liver tumours showed rapid and sustained tumour regression when treated with doxycycline to inactivate

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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Shachaf, C. M.

et al. MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. _Nature_ 10 Oct 2004 (doi:10.1038/nature03043) Download references Authors * Ezzie

Hutchinson View author publications You can also search for this author inPubMed Google Scholar RELATED LINKS RELATED LINKS WEB SITE Dean Felsher's lab RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hutchinson, E. Inducing dormancy. _Nat Rev Cancer_ 4, 834 (2004). https://doi.org/10.1038/nrc1485 Download citation * Issue Date: 01

November 2004 * DOI: https://doi.org/10.1038/nrc1485 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link

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