Tnf inhibitors plus cyclophosphamide could increase patients' cancer risk


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Access through your institution Buy or subscribe Stone JH _ et al_. (2006) Solid malignancies among patients in the Wegener's granulomatosis etanercept trial. _Arthritis Rheum_ 54:


1608–1618 Tumor necrosis factor (TNF) induces apoptosis in several tumor types. TNF inhibitors have become a mainstay of treatment in many inflammatory conditions, although it has been


suggested that these agents could increase patients' risk of developing cancer. To date, these concerns have principally focused on lymphoma; however, Stone _ et al_. now report that


patients treated with both a TNF inhibitor and cyclophosphamide might have an increased risk of developing solid tumors, beyond the risk attributable to cyclophosphamide alone. This is a


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published with the same DOI as a previous publication. A new DOI has been assigned and registered at Crossref, and has been corrected in the article. _ RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE TNF inhibitors plus cyclophosphamide could increase patients' cancer risk. _Nat Rev Clin Oncol_ 3, 414–415 (2006).


https://doi.org/10.1038/ncprheum0237x Download citation * Issue Date: 01 August 2006 * DOI: https://doi.org/10.1038/ncprheum0237x SHARE THIS ARTICLE Anyone you share the following link with


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