A central role for s-nitrosylation in apoptosis

New work reveals a key signal transduction pathway through which nitric oxide (NO) regulates apoptosis induced by disparate cellular stresses. Glyceraldehyde-3-phosphate dehydrogenase

(GAPDH) is _S_-nitrosylated by NO, which initiates an interaction with the E3 ligase Siah1, leading to nuclear translocation and ubiquitin-mediated degradation of nuclear target proteins.

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of Medicine, Howard Hughes Medical Institute, Room 321 MSRB, Box 2612, Duke University Medical Center, Durham, 27710, NC, USA Moran Benhar & Jonathan S. Stamler Authors * Moran Benhar

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Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Benhar, M., Stamler, J. A central role for _S_-nitrosylation in apoptosis. _Nat Cell Biol_ 7,

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