Prevalence of paroxysmal atrial fibrillation depending on the regression of left ventricular hypertrophy in arterial hypertension

ABSTRACT Arterial hypertension (HTN) represents one of the major causes of atrial fibrillation, a cardiac arrhythmia with high prevalence and comorbidity. The aim of this study was to

investigate whether paroxysmal atrial fibrillation can be treated by the regression of left ventricular hypertrophy achieved by antihypertensive therapy. Included in the present study were

104 patients who had had HTN for more than 1 year. None of them suffered from coronary heart disease. All patients were investigated by 24-h Holter ECG and echocardiography at baseline and

after a mean of 24 months. Patients were divided into two groups: group A consisted of those (53.8%) who showed a regression of the left ventricular muscle mass index (LVMMI) during the

follow-up (154.9±5.1 _vs_. 123.5±2.8 g/m2), and group B those (45.2%) who showed a progression of LVMMI (122.2±3.2 _vs_. 143.2±3.2 g/m2). In group A the prevalence of atrial fibrillation

decreased from 12.5% to 1.8% (_p_<0.05), while it was increased in group B from 8.5% to 17.0%. The left atrial diameter was reduced following antihypertensive therapy in group A from

39.1±5.3 mm to 37.4±4.6 mm (_p_<0.01) and increased in group B from 37.0±0.7 mm to 39.0±0.9 mm (_p_<0.01). We conclude that a regression of the left ventricular muscle mass leads to a

reduction of left atrial diameter and consecutively to a decrease in the prevalence of intermittent atrial fibrillation. This may be explained by a better left ventricular diastolic function

following decreased vascular and extravascular resistance of the coronary arteries. This relation shows the benefits of causal antihypertensive therapy for the treatment of paroxysmal

atrial fibrillation. SIMILAR CONTENT BEING VIEWED BY OTHERS DIASTOLIC DYSFUNCTION, HYPERTROPHY AND HYPERTENSION VENTRICULAR-ARTERIAL UNCOUPLING TREATMENT Article 14 October 2022

AGE-DEPENDENT IMPLICATIONS OF LEFT VENTRICULAR HYPERTROPHY REGRESSION IN PATIENTS WITH HYPERTENSION Article 18 January 2024 AMBULATORY BLOOD PRESSURE IS ASSOCIATED WITH LEFT VENTRICULAR

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AUTHORS AND AFFILIATIONS * Department of Cardiology, Pneumology and Angiology, Heinrich-Heine-University, Duesseldorf, Germany Marcus G Hennersdorf, Per O Schueller, Stephan Steiner & 

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search for this author inPubMed Google Scholar * Stephan Steiner View author publications You can also search for this author inPubMed Google Scholar * Bodo E Strauer View author

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THIS ARTICLE CITE THIS ARTICLE Hennersdorf, M., Schueller, P., Steiner, S. _et al._ Prevalence of Paroxysmal Atrial Fibrillation Depending on the Regression of Left Ventricular Hypertrophy

in Arterial Hypertension. _Hypertens Res_ 30, 535–540 (2007). https://doi.org/10.1291/hypres.30.535 Download citation * Received: 20 September 2006 * Accepted: 25 January 2007 * Issue Date:

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link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * atrial fibrillation * left ventricular

hypertrophy * arterial hypertension