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It is generally believed that the expression of a gene is restricted “within the right place and at the right time”. This principle has long been considered applicable as well to the
expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig “paradoxically” expressed in malignant tumors of epithelial origin. We reviewed the
recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of
immunology and oncology.
Duosha Hu and Hui Zheng: These two author contributed equally to this paper
Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
Duosha Hu, Hui Zheng, Haidan Liu, Ming Li, Wei Ren, Wei Liao, Zhi Duan, Lili Li & Ya Cao
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