Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukaemia of childhood

ABSTRACT Pretreatment marrow blast cells were studied in 38 boys and 27 girls (aged 1-14) with acute lymphoblastic leukaemia by flow cytometry after staining with propidium iodide. The

percentage of blast cells in the S phase of the cell cycle ranged from 1% to 40% (median 6%). A correlation was found between the percentage of cells in S and the morphological

classification of the French American British Cooperative Group (FAB), presence of T or B cell markers, haemoglobin concentration, blast size, bone pain, platelet count, and an inverse

correlation with coarse granule and block staining with Periodic-acid-Schiff (PAS). 63 of the 65 children attained complete remission. During the first 24 months of follow up there were

fewer relapses (_P_ = 0·054), and deaths (_P_ = 0·004) in those children with 6% or fewer blasts in S phase. The difference was most marked in the first 12 months with 4 relapses out of 33

in the group with 6% or fewer cells in S compared with 13/30 in the group with > 6% cells in S. In order to investigate the prognostic significance of the pretreatment proliferative

studies in greater detail, remission duration was correlated with 17 presenting features. Each feature was correlated individually and then the simultaneous effect of all the features was

assessed by stepwise multiple regression. Only 3 features of the disease at diagnosis were individually correlated with duration of remission. These were% cells in S (_P_ < 0·001), log

white cell blood count (WBC) (_P_ < 0·01) and the presence of T- or B-cell surface markers (_P_ < 0·05). However, the multiple regression analysis showed that cell markers were not an

independent prognostic feature, whereas the percentage cells in S and log WBC were independently and significantly correlated with duration of first remission (_P_ < 0·001 in each case).

Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this

journal Receive 24 print issues and online access $259.00 per year only $10.79 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now

Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer

support SIMILAR CONTENT BEING VIEWED BY OTHERS IMMUNOPHENOTYPIC ASSESSMENT OF CLONAL PLASMA CELLS AND B-CELLS IN BONE MARROW AND BLOOD IN THE DIAGNOSTIC CLASSIFICATION OF EARLY STAGE

MONOCLONAL GAMMOPATHIES: AN ISTOPMM STUDY Article Open access 11 December 2023 TEMPORAL EVOLUTION AND DIFFERENTIAL PATTERNS OF CELLULAR RECONSTITUTION AFTER THERAPY FOR CHILDHOOD CANCERS

Article Open access 10 March 2023 INCREASE IN POLYMORPHONUCLEAR MYELOID-DERIVED SUPPRESSOR CELLS AND REGULATORY T-CELLS IN CHILDREN WITH B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA Article Open

access 22 July 2021 Authors * J H Scarffe View author publications You can also search for this author inPubMed Google Scholar * I M Hann View author publications You can also search for

this author inPubMed Google Scholar * D I K Evans View author publications You can also search for this author inPubMed Google Scholar * P. Morris Jones View author publications You can also

search for this author inPubMed Google Scholar * M K Palmer View author publications You can also search for this author inPubMed Google Scholar * J S Lilleyman View author publications You

can also search for this author inPubMed Google Scholar * D Crowther View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Scarffe, J., Hann, I., Evans, D. _et al._ Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis

of acute lymphoblastic leukaemia of childhood. _Br J Cancer_ 41, 764–771 (1980). https://doi.org/10.1038/bjc.1980.139 Download citation * Issue Date: 01 May 1980 * DOI:

https://doi.org/10.1038/bjc.1980.139 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative