Rel blocks both anti-fas- and tnfα-induced apoptosis and an intact rel transactivation domain is essential for this effect

ABSTRACT The v-Rel oncoprotein must be continuously expressed to prevent the apoptosis of transformed lymphoid cells, and also inhibits TNFα-induced cell death. A tetracycline-regulated cell

system was used to characterize the functions necessary for the anti-apoptotic activity of Rel proteins. v-Rel mutants defective for DNA binding or transactivation showed no protective

effect. Similarly, whereas the transcription-competent c-Rel and RelA proteins inhibited TNFα-induced cytolysis, the transactivation-negative p50/NF-κB1 did not. Importantly, this study is

the first to show that c-Rel can also confer significant protection from Fas-mediated cell death. Since the TNFR1- and Fas-signaling pathways involve some intermediates that are common and

others that are unique to each pathway, these findings indicate that c-Rel may regulate the expression of genes that function to antagonize either or both death-signaling pathways. SIMILAR

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NF-ΚB ACTIVATION AND SURVIVAL Article Open access 03 May 2023 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Center for Advanced Biotechnology and Medicine, Piscataway,

08854-5638, New Jersey, USA Wei-xing Zong, Judy Bash & Céline Gélinas * Graduate Program in Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, Robert

Wood Johnson Medical School, Piscataway, 08854-5638, New Jersey, USA Wei-xing Zong * Graduate Program in Microbiology and Molecular Genetics, Rutgers University, Piscataway, 08854-5638, New

Jersey, USA Judy Bash * Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, and Cancer Institute of New Jersey, Piscataway,

08854-5638, New Jersey, USA Céline Gélinas Authors * Wei-xing Zong View author publications You can also search for this author inPubMed Google Scholar * Judy Bash View author publications

You can also search for this author inPubMed Google Scholar * Céline Gélinas View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Céline Gélinas. ADDITIONAL INFORMATION Edited by B.A. Osborne RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zong, Wx., Bash, J. &

Gélinas, C. Rel blocks both anti-Fas- and TNFα-induced apoptosis and an intact Rel transactivation domain is essential for this effect. _Cell Death Differ_ 5, 963–972 (1998).

https://doi.org/10.1038/sj.cdd.4400441 Download citation * Received: 06 February 1998 * Revised: 22 May 1998 * Accepted: 15 July 1998 * Published: 03 November 1998 * Issue Date: 01 November

1998 * DOI: https://doi.org/10.1038/sj.cdd.4400441 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link

is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Rel * NF-κB * apoptosis * TNFα * Fas