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ABSTRACT Prostacyclin (PGI2), an unstable metabolite of arachidonic acid synthesized by vascular endothelial and smooth muscle cells, is a potent vasodilator and endogenous inhibitor of
platelet aggregation1–10. Regulation of PGI2 synthesis by the vessel wall is not well understood11–16. We have investigated the possibility that a product released from platelet granules
during degranulation might modify vessel wall PGI2 biosynthesis. We report here that a non-dialysable, platelet-dependent factor in serum dramatically stimulates PGI2 synthesis by cultured
bovine aortic endothelium, aortic smooth muscle, and adrenal capillary endothelium. Platelet-derived growth factor (PDGF), a releasable peptide contained within platelet alpha granules17–20,
stimulates PGI2 synthesis by the above cell types as much as 100-fold. The concentrations of PDGF required to produce these effects are below the level reported in normal human serum18. We
postulate that _in vivo_ released PDGF may increase vessel wall PGI2 production as part of a negative feedback mechanism controlling platelet aggregation. Access through your institution Buy
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OTHERS THE ANTIPLATELET AGENT REVACEPT PREVENTS THE INCREASE OF SYSTEMIC THROMBOXANE A2 BIOSYNTHESIS AND NEOINTIMA HYPERPLASIA Article Open access 08 December 2020 COLCHICINE INHIBITS ROS
GENERATION IN RESPONSE TO GLYCOPROTEIN VI STIMULATION Article Open access 07 June 2021 SPHINGOSINE-1-PHOSPHATE MODULATES PAR1-MEDIATED HUMAN PLATELET ACTIVATION IN A CONCENTRATION-DEPENDENT
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Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Neural and Endocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of
Technology, Cambridge, Massachusetts, 02139 Shaun R. Coughlin & Michael A. Moskowitz * Section of Neurology, Department of Medicine, Peter Bent Brigham Hospital, Harvard Medical School,
Boston, Massachusetts, 02115 Michael A. Moskowitz * Department of Surgery, Children's Hospital Medical Center, Harvard Medical School, Boston, Massachusetts, 02115 Bruce R. Zetter *
Center for Blood Research, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, 02115 Harry N. Antoniades * Department of Biochemistry, Brandeis University,
Waltham, Massachusetts, 02154 Lawrence Levine Authors * Shaun R. Coughlin View author publications You can also search for this author inPubMed Google Scholar * Michael A. Moskowitz View
author publications You can also search for this author inPubMed Google Scholar * Bruce R. Zetter View author publications You can also search for this author inPubMed Google Scholar * Harry
N. Antoniades View author publications You can also search for this author inPubMed Google Scholar * Lawrence Levine View author publications You can also search for this author inPubMed
Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Coughlin, S., Moskowitz, M., Zetter, B. _et al._ Platelet-dependent stimulation of
prostacyclin synthesis by platelet-derived growth factor. _Nature_ 288, 600–602 (1980). https://doi.org/10.1038/288600a0 Download citation * Received: 24 July 1980 * Accepted: 16 October
1980 * Issue Date: 11 December 1980 * DOI: https://doi.org/10.1038/288600a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link
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