Α adrenoreceptors but not β adrenoreceptors increase in rabbit uterus with oestrogen


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ABSTRACT STEROID hormones alter sympathetic function and modulate responses to catecholamines1–3. The gonadal steroids, oestrogen and progesterone, can affect sympathetic response by


altering catecholamine metabolism, and, in addition, they produce qualitative changes in the contractile response of smooth muscle to stimulation by adrenaline and noradrenaline4–6. The


response of human oviduct and uteri from several species changes from contraction to relaxation depending upon the concentrations of gonadal steroids. Contraction, which is mediated by


_α_-adrenergic receptors, is observed in uteri from oestrogen-treated humans or rabbits, while relaxation, a _β_-adrenergic response, predominates during pregnancy or with progesterone


treatment. Conversion between _α_ and _β_ response, depending on hormonal or other environmental factors, has prompted the hypothesis that _α_- and _β_-adrenergic receptors may be


interconvertible7–9. We used the radioligands 3H-dihydroergocryptine (DHE) and 125I-iodohydroxybenzylpindolol ([125I] IHYP) to quantitate _α_- and _β_-adrenergic receptors respectively in


subcellular preparations of uteri from rabbits treated with oestrogen or oestrogen followed by progesterone. _α_-Adrenergic binding sites were three times greater in uteri from the


oestrogen-treated animals in which _α_-adrenergic response was predominant than in uteri from animals treated with oestrogen followed by progesterone in which _β_-adrenergic response


predominates. The number of _β_-adrenergic binding sites was unchanged by the different treatments and these sites were only 5% as numerous as α-adrenergic sites. These findings suggest that


gonadal steroids may alter smooth muscle adrenergic response by alterations of adrenergic receptor number and do not support the hypothesis that _α_- and _β_-adrenergic receptors are simply


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Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Obstetrics, Gynecology and Reproductive Sciences, Medicine and the Cardiovascular Research


Institute, University of California, San Francisco, San Francisco, California, 94143 JAMES M. ROBERTS, PAUL A. INSEL, ROBERT D. GOLDFIEN & ALAN GOLDFIEN Authors * JAMES M. ROBERTS View


author publications You can also search for this author inPubMed Google Scholar * PAUL A. INSEL View author publications You can also search for this author inPubMed Google Scholar * ROBERT


D. GOLDFIEN View author publications You can also search for this author inPubMed Google Scholar * ALAN GOLDFIEN View author publications You can also search for this author inPubMed Google


Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE ROBERTS, J., INSEL, P., GOLDFIEN, R. _et al._ α adrenoreceptors but not β adrenoreceptors


increase in rabbit uterus with oestrogen. _Nature_ 270, 624–625 (1977). https://doi.org/10.1038/270624a0 Download citation * Received: 12 August 1977 * Accepted: 17 October 1977 * Issue


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