Systemic humoral factors participating in the course of spinal cord injury

ABSTRACT Systemic humoral factors have been studied in traumatic, chronic and acute spinal cord injured patients. Antibodies specific to nervous system autoantigens were detected in a

majority of the sera obtained from these patients, at different periods after injury. Limited _in vitro_ sprouting of dorsal root ganglia in chicken embryos was observed in the presence of

serum from these patients. The possible association between growth inhibiting factors and the presence of antibodies against nervous tissue autoantigens is discussed. SIMILAR CONTENT BEING

VIEWED BY OTHERS THE COMBINATION TREATMENT OF METHYLPREDNISOLONE AND GROWTH FACTOR-RICH SERUM AMELIORATES THE STRUCTURAL AND FUNCTIONAL CHANGES AFTER SPINAL CORD INJURY IN RAT Article 25

November 2023 SPINAL CORD INJURY CAUSES CHRONIC BONE MARROW FAILURE Article Open access 24 July 2020 EARLY AND SUSTAINED IMPROVEMENTS IN MOTOR FUNCTION IN RATS AFTER INFUSION OF ALLOGENEIC

UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS FOLLOWING SPINAL CORD INJURY Article 02 November 2020 ARTICLE PDF REFERENCES * Ando, S & Yu, R K (1977). Isolation and characterization of a

novel trisialoganglioside GTla from human brain. _J. Biol. Chem._, 252, 6247. CAS  PubMed  Google Scholar  * Aviel, A & Schwartz, M Sprouting inducing activity of human sera: Low

capacity in sera from patients with cranial poly neuropathy. _J. Neurosci. Res., (in press)_. * Berry, M & Riches, A C (1974). An immunological approach to regeneration in the central

nervous system. _Br. Med. Bull._, 30, 135. Article  CAS  Google Scholar  * Bill, H A, Seibert, E S, Bekwith, J B & Hartman, J R (1969). Nerve growth factor and nerve growth-stimulating

activity in sera from normal and neuroblastoma patients. _J. Natl. Cancer Inst._, 43, 1221. CAS  PubMed  Google Scholar  * Caspary, E A & Chambers, M E (1970). Antibody to

encephalitogenic basic protein in multiple sclerosis and other neurological diseases as measured by immune adherence. _Europ. Neurol._, 3, 206. Article  CAS  Google Scholar  * Cook, S D

& Dowling, P C (1981). The role of autoantibody and immune complexes in the pathogenesis of Guillain-Barre syndrome. _Ann. Neurol._, 9 (suppl), 70. Article  Google Scholar  * De La

Torre, J C (1981). Spinal cord injury: Review of basic and applied research. _Spine_, 6, 315. Article  CAS  Google Scholar  * Den, H, Sela, B, Roseman, S & Sachs, L (1974). Blocks in

gangliosides synthesis in transformed hamster cells and their revertance. _J Biol, Chem._, 29, 659. * Gorio, A, Carmignoto, G, Facci, L & Finesso, M (1980). Motor nerve sprouting induced

by ganglioside treatment: Possible implications for gangliosides on neuronal growth. _Brain. Res._, 197, 236. Article  CAS  Google Scholar  * Hirshfeld, H, Teitelbaum, D, Annon, R &

Sella, M (1970). Basic encephalitogenic protein: a simplified purification on sulphoethyl-sephadex. _FEB S Lett._, 7, 717. Article  Google Scholar  * Hunter, W M (1973). Radioimmunoassay,

in: _Handbook of Experimental Immunology_, chapter 17. Oxford: Blackwell Scientific Publications. Google Scholar  * Kiernan, J A (1979). Hypotheses concerned with axonal regeneration in the

mammalian nervous system. _Biol. Rev._, 54, 155. Article  CAS  Google Scholar  * Levi-Montalcini, R & Hamburger, V (1951). Selective growth stimulating effects of mouse sarcoma on the

sensory and sympathetic nervous syste, of the chick embryo. _J. Exp. Zool._, 116, 321. Article  CAS  Google Scholar  * Levi-Montalcini, R & Hamburger, V (1953). A diffusable agent of

mouse sarcoma producing hyperplasia of sympathetic ganglia and hyperneurotization of chick embryo. _J. Exp. Zool._, 123, 233. Article  Google Scholar  * McDonald, W I (1975). Mechanisms of

functional loss and recovery in spinal cord damage. Outcome of severe damage to the central nervous system. _CIBA Foundation Symposium_, 34, Amsterdam: Elsevier, pp. 23–29. Google Scholar  *

McConnell, P & Berry, M (1982). Regeneration of ganglion cell axons in the adult mouse retina. _Brain Res._, 241, 362. Article  CAS  Google Scholar  * Schwartz, M, Novik, D, Givol, D

& Fuchs, S (1978). Induction of anti-idiotypic antibodies by immunization with syngeneic spleen cells educated with acetylcholine receptor. _Nature_, 273, 543. Article  CAS  Google

Scholar  * Schwartz, M & Spirman, N (1982). Sprouting from chick embryo dorsal root ganglia induced by nerve growth factor is specifically inhibited by affinity purified anti-GMI

antibodies. _Proc. Natl. Acad. Sci._, 79, 6080. Article  CAS  Google Scholar  * Schwartz, M, Sela, B A & Eshhar, N (1982). Production of antibodies against auto-antigens induced by

peripheral nerve injury in mice. _J. Neurochem._, 38, 1192. Article  CAS  Google Scholar  * Spirman, N, Sela, B A & Schwartz, M (1982). Anti-ganglioside antibodies inhibit outgrowth from

regenerating goldfish retinal explant. _J. Neurochem._, 39, 874. Article  CAS  Google Scholar  * Varon, S & Adler, R (1981). Trophic and specifying factors directed to neuronal cells.

_Adv. Cell Neurobiol._, 2, 115. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Neurobiology, The Weizmann Institute of Science,

Rehovot, Israel Y Mizrachi & M Schwartz * The Neurological Rehabilitation Department, The Chaim Sheba Medical Centre Tel Ha Shomer and Sackler School of Medicine, Tel Aviv University,

Israel A Ohry, A Aviel, R Rozin & M E Brooks Authors * Y Mizrachi View author publications You can also search for this author inPubMed Google Scholar * A Ohry View author publications

You can also search for this author inPubMed Google Scholar * A Aviel View author publications You can also search for this author inPubMed Google Scholar * R Rozin View author publications

You can also search for this author inPubMed Google Scholar * M E Brooks View author publications You can also search for this author inPubMed Google Scholar * M Schwartz View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mizrachi, Y., Ohry, A., Aviel,

A. _et al._ Systemic humoral factors participating in the course of spinal cord injury. _Spinal Cord_ 21, 287–293 (1983). https://doi.org/10.1038/sc.1983.48 Download citation * Issue Date:

01 October 1983 * DOI: https://doi.org/10.1038/sc.1983.48 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Spinal cord injury * Systemic humoral

factors