Immunotherapeutic suppression in transplantable solid tumours

ABSTRACT α-FOETOPROTEIN (AFP) is a glycoprotein, of unknown function, synthesised by the foetal liver and yolk sac of mammals1. Increased serum levels of AFP in adults are indicative of

either pregnancy or a pathological state, that is primary hepatocellular carcinoma, regenerating liver and teratoblastomas of the ovary and testis2,3. Recently, abnormal levels of AFP in

amniotic fluids have been correlated with foetal distress4. While attempting to study the physiological role of AFP during ontogenic and oncogenic growth, we have observed an interaction

between AFP and its homologous antiserum that may have immunotherapeutic value. We report here the suppression of mouse hepatoma growth _in vivo_ and _in vitro_ using passively administered

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IN THE TUMOR MICROENVIRONMENT OF FIBROLAMELLAR CARCINOMA VIA PD-1 AND IL-10 BLOCKADE Article Open access 01 March 2024 REFERENCES * Gitlin, D., and Boesman, M., _J. clin. Invest._, 46, 1010

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AND AFFILIATIONS * Department of Biology, University of South Carolina, Columbia, South Carolina, 29208 GERALD J. MIZEJEWSKI & ROBLEE P. ALLEN Authors * GERALD J. MIZEJEWSKI View author

publications You can also search for this author inPubMed Google Scholar * ROBLEE P. ALLEN View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE MIZEJEWSKI, G., ALLEN, R. Immunotherapeutic suppression in transplantable solid tumours. _Nature_ 250, 50–52 (1974).

https://doi.org/10.1038/250050a0 Download citation * Received: 11 February 1974 * Revised: 18 April 1974 * Published: 01 July 1974 * Issue Date: 05 July 1974 * DOI:

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