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ABSTRACT OBJECTIVE: Hormesis, the biological and toxicological concept that small quantities have opposite effects from large quantities, is reviewed with emphasis on its relevance to
nutrition. RESULTS: Hormetic and other dose–response relationships are categorized, depicted, and discussed. Evidence for nutritional hormesis is presented for essential vitamin and mineral
nutrients, dietary restriction, alcohol (ethanol), natural dietary and some synthetic pesticides, some herbicides, and acrylamide. Some of the different hormetic mechanisms that have been
proposed are reviewed. CONCLUSIONS: The credence and relevance of hormesis to nutrition are considered to be established. The roles of hormesis in nutritional research and in formulating
nutritional guidelines are discussed. SPONSORSHIP: The New York City Department of Health and Mental Hygiene. Access through your institution Buy or subscribe This is a preview of
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VITAMIN D RANDOMISED CONTROL TRIALS AND CHARACTERISING FACTORS AFFECTING IT THROUGH A NOVEL SIMULATION-BASED TOOL Article Open access 24 May 2021 TOWARDS NUTRITION WITH PRECISION: UNLOCKING
BIOMARKERS AS DIETARY ASSESSMENT TOOLS Article 02 July 2024 NUTRIENT CONCENTRATIONS IN FOOD DISPLAY UNIVERSAL BEHAVIOUR Article 24 May 2022 REFERENCES * Ames BN (1998). Micronutrients
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stakhanovite efforts and services of the staff of the William Hallock Park Memorial Public Health Library of the New York City Department of Health and Mental Health Hygiene and the
technical assistance of my colleague Raymond Ford. I have no conflicts of interest that are either directly or indirectly relevant to the content of this article. AUTHOR INFORMATION AUTHORS
AND AFFILIATIONS * New York City Department of Health and Mental Hygiene, New York, NY, USA D P Hayes Authors * D P Hayes View author publications You can also search for this author
inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to D P Hayes. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hayes, D. Nutritional hormesis.
_Eur J Clin Nutr_ 61, 147–159 (2007). https://doi.org/10.1038/sj.ejcn.1602507 Download citation * Received: 02 January 2006 * Revised: 31 May 2006 * Accepted: 09 June 2006 * Published: 02
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* dose–response relationships * dietary restriction * alcohol/ethanol * pesticides * acrylamide