2022 national research week | va louisville health care | veterans affairs

This week marks the 97th anniversary of VA Research and is being celebrated as National Research Week across the country. VA research is often the channel for new technologies to be

introduced, federally approved, and brought to the global mainstream clinical environment. VA researchers are part of the innovative teams that developed effective treatments for

tuberculosis, invented the CAT scan, and performed the first-ever liver transplant. Cutting-edge research is more robust today than ever at VA medical centers nationwide. VA research is

working to improve Veterans' lives through health care discovery and innovation. To learn more about research being conducted at the Robley Rex VAMC, click HERE. CURRENT RESEARCH  The

laboratory of DR. ELEANOR LEDERER and DR. MICHAEL BRIER at the Robley Rex VAMC has been focused on improving health care for our Veterans with kidney disease. Two major complications facing

this population is the control of anemia and metabolic bone disease - the major causes of morbidity and mortality in these patients. Over the last two decades, their research has developed

an artificial intelligence tool for drug-dosing that improves anemia management and reduces patient exposure to drugs used in this treatment. Currently, Dr. Lederer and Dr. Brier are

adapting these principles for a more complicated disease: metabolic bone disease. Their work has resulted in the development of a mathematical model of the human body suffering kidney

disease. This model can be used to test multiple drug therapies used in the treatment of this disease. Results to date show that an artificial intelligence approach is superior to the

methodology being currently used. The desired result of the drug therapy is achieved quicker and with improved markers of bone health. Current research is looking to expand the techniques

developed in this work to further improve patient's health. Human trials utilizing this methodology are beginning and will lead to randomized controlled clinical trials of the

technology. In conjunction with the Non-profit Research Center, our clinical investigators have initiated several new research trials. These trials range from diabetes care to cancer, and

inflammatory bowel disease to pancreatitis. We are also conducting trials in liver cancer and lung cancer. DR. FRED HENDLER was awarded a $5 million grant for studying lung cancer treatments

and early detection/prevention. This grant covers the research being conducted in conjunction with four other VISN 9 hospitals, extending the reach of Robley Rex VAMC investigators much

wider than it has reached in the past.  Dr. Hendler is also investing new technology that can detect cancer DNA in the blood that might lead to early detection of several different types of

cancer.  DR. GERALD DRYDEN has several studies investigating new agents in Crohn’s and ulcerative colitis. These new medications have successfully treated Crohn’s disease in earlier trials,

and now they are undergoing final evaluation before being submitted to the FDA. These medications affect the immune system in different ways than older medications - bringing greater benefit

with a smaller side effect profile. Dr. Gerald Dryden is studying a new medication designed to combat acute pancreatitis. This medication works by inhibiting calcium channels, which are

important to the development of pancreatitis and the ensuing immune response. This study is for hospitalized patients with acute pancreatitis from any cause. DR. SATHYA KRISHNASAMY is

conducting clinical trials to evaluate the effect of new medicines on diabetes and obesity. Her past efforts have assisted in moving recently approved medications for diabetes and obesity

from clinical trials to actual use in clinics. Some of the therapies that she is investigating show promise to further improve the care of these diseases. Newer medications being developed

for obesity are showing great promise for reducing obesity and the complications associated with that condition. DR. BOBBY MOLDOVEANU is conducting a study evaluating a novel stimulator of

the diaphragm to assist patients on a ventilator to breath better on their own. This will enable patients to be removed from a ventilator in a timelier manner. DR. ASHUTOSH BARVE is

investigating new therapies for patients with advanced liver disease with new drugs targeting hepatocellular carcinoma - a cancer of the liver that develops in the setting of cirrhosis. 

These new therapies provide hope to people that would otherwise result in prolonged suffering and eventually death.  DR. CRAIG MCCLAIN has started up a new study looking at the effects of a

common medication for controlling cholesterol (simvastatin), with the hope that this medication will help prevent serious complications of advanced liver disease (cirrhosis). The Robley Rex

VAMC is one of only nine other sites across the VA healthcare system to conduct this research.