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In this Viewpoint, Michael Farkouh and colleagues question the evidence that C-reactive protein (CRP) is an independent predictor of future cardiovascular events. They suggest that failure
to adjust for all components of the metabolic syndrome (MetS) in previous studies has bought into question the value of CRP over established traditional risk factors. The authors postulate
that CRP is only a marker of the MetS and has limited incremental value in cardiovascular risk stratification.
Programmed ventricular stimulation has been proposed as a method of risk stratification in patients with repaired tetralogy of Fallot. In this Viewpoint, Paul Khairy reveals how Bayes'
theorem can be used to identify patients most likely to benefit from programmed ventricular stimulation, and to demonstrate that routine electrophysiological testing is unnecessary.
The causes of transient ischemic attack (TIA) are identical to those for stroke; however, there are many unresolved issues regarding acute treatment for TIA. Here Mai Nguyen-Huynh and S
Claiborne Johnston review the recent literature on stroke risk after TIA and the guidelines on evaluation and treatment.
Pulmonary arterial hypertension (PAH) was once a lethal condition. As the number of therapeutic options available has risen, however, the treatment of PAH has evolved considerably. In this
Review, Aniket Puri, Michael McGoon and Sudhir Kushwaha consider the current knowledge of the pathogenesis of PAH in relation to presently available and novel emerging therapies, including
combination therapy, that hold promise for treatment as well as disease modification.
In light of advances in imaging technology, awareness of the clinical significance of thoracic aortic aneurismal disease has increased in recent years and allowed earlier diagnosis. In this
Surgery Insight, James Davies and Thoralf Sundt examine the indications for surgical intervention on the dilated aorta, particularly the ascending segment. They discuss the management
options currently available and provide their clinical recommendations for follow-up.
