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RAS HITCHHIKES ON PDE6Δ Ras GTPases are tethered to cellular membranes by a farnesyl lipid that modifies a carboxy-terminal cysteine. One of the ways Ras traffics between membranes is via
fluid-phase diffusion, suggesting that a cytosolic chaperone might be needed to shield the farnesyl lipid during transport. PDE6δ is now revealed to be a farnesyl-binding chaperone that
facilitates the trafficking and signalling of Ras. * Mark R. Philips
