Baclofen-induced frontal lobe syndrome


Play all audios:

ABSTRACT An 81-year-old man with cervical spondylotic myelopathy developed an acute frontal lobe like syndrome with prominent perseveration and an abnormal electroencephalogram after being


given seven doses (70 mg) of baclof en for spasticity. The clinical symptoms cleared up in 72 hours after the medication was discontinued. SIMILAR CONTENT BEING VIEWED BY OTHERS


LEVETIRACETAM TREATMENT LEADS TO FUNCTIONAL RECOVERY AFTER THORACIC OR CERVICAL INJURIES OF THE SPINAL CORD Article Open access 02 March 2021 MONOAMINE CONTROL OF DESCENDING PAIN MODULATION


AFTER MILD TRAUMATIC BRAIN INJURY Article Open access 29 September 2022 THE NEUROPHYSIOLOGICAL EFFECT OF NMDA-R ANTAGONISM OF FRONTOTEMPORAL LOBAR DEGENERATION IS CONDITIONAL ON INDIVIDUAL


GABA CONCENTRATION Article Open access 27 August 2022 ARTICLE PDF REFERENCES * Abarbanel J, Herishanu Y, Frisher S 1985 Encephalopathy associated with baclofen. _Ann Neurology_ 17: 617–618.


Article  CAS  Google Scholar  * Bowery N G, Hill D R, Hudson A L et al 1980 (-) Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor.


_Nature_ 283: 92–94. Article  CAS  Google Scholar  * Faigle J W, Keberle H 1972 The chemistry and kinetics of Lioresal. _Postgraduate Medical Journal_ (SUPPL5)4S: 9–13. Google Scholar  *


Hormes J T, Benarroch E E, Rodriguez M, Klass D W 1988 Periodic sharp waves in baclofen-induced encephalopathy. _Archives of Neurology_ 45: 814–815. Article  CAS  Google Scholar  *


Javoy-Agid F, Scatton B, Ruberg M et al., 1989 Distribution of monoaminergic, cholinergic, and gabaergic markers in the human cerebral cortex. _Neuroscience_ 29: 251–259. Article  CAS 


Google Scholar  * Knuttson E, Lindblom U, Martensson A 1974 Plasma and cerebrospinal fluid levels of baclofen at optimal therapeutic responses in spastic paresis. _Journal of Neurological


Science_ 23: 473–484. Article  Google Scholar  * Sachais B A, Logue J N, Carey M S 1977 Baclofen, a new antispastic drug: A controlled, multicenter trial in patients with multiple sclerosis.


_Archives of Neurology_ 34: 422–428. Article  CAS  Google Scholar  * White W B 1985 Aggravated CNS depression with urinary retention secondary to baclofen administration. _Archives of


International Medicine_. 145: 1717–1718. Article  CAS  Google Scholar  * Yassa R Y, Iskandar H L 1988 Baclofen-induced psychosis: Two cases and a review. _Journal of Clinical Psychiatry_ 49:


318–320. CAS  PubMed  Google Scholar  * Young R R, DELWAlDE P J 1981 Spasxicity. _New England Journal of Medicine_ 304: 28-33,96-99. Article  Google Scholar  Download references AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Neurological Center, Taipei, Taiwan, Republic of China Hsiu-Chih Liu & Shi-Ching Tsai * Department of Medical Research, Veterans General


Hospital-Taipei, Taipei, Taiwan, Republic of China Tsung-Yun Liu & Chin-Wen Chi Authors * Hsiu-Chih Liu View author publications You can also search for this author inPubMed Google


Scholar * Shi-Ching Tsai View author publications You can also search for this author inPubMed Google Scholar * Tsung-Yun Liu View author publications You can also search for this author


inPubMed Google Scholar * Chin-Wen Chi View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE


CITE THIS ARTICLE Liu, HC., Tsai, SC., Liu, TY. _et al._ Baclofen-induced frontal lobe syndrome. _Spinal Cord_ 29, 554–556 (1991). https://doi.org/10.1038/sc.1991.80 Download citation *


Issue Date: 01 October 1991 * DOI: https://doi.org/10.1038/sc.1991.80 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry,


a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Baclof en * Cervical


spondylotic myelopathy * Spasticity * Confusional state