A chemical toolbox for surface engineering of extracellular vesicles

feature-image

Play all audios:

Loading...

Surface engineering enhances the pharmacokinetics and pharmacodynamics of extracellular vesicles (EVs) by improving their stability, immune evasion, tracking and targeting. Advancing


scalable chemical approaches that preserve the integrity and functionality of EVs and efficient purification methods are key to unlocking their full potential. Access through your


institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12


digital issues and online access to articles $119.00 per year only $9.92 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices


may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support


REFERENCES * van Niel, G., D’Angelo, G. & Raposo, G. Shedding light on the cell biology of extracellular vesicles. _Nat. Rev. Mol. Cell Biol._ 19, 213–228 (2018). Article  Google Scholar


  * Toyofuku, M., Schild, S., Kaparakis-Liaskos, M. & Eberl, L. Composition and functions of bacterial membrane vesicles. _Nat. Rev. Microbiol._ 21, 415–430 (2023). Article  Google


Scholar  * Herrmann, I. K., Wood, M. J. A. & Fuhrmann, G. Extracellular vesicles as a next-generation drug delivery platform. _Nat. Nanotechnol._ 16, 748–759 (2021). Article  Google


Scholar  * Richter, M., Vader, P. & Fuhrmann, G. Approaches to surface engineering of extracellular vesicles. _Adv. Drug Deliv. Rev._ 173, 416–426 (2021). Article  Google Scholar  *


Nguyen, S. S. & Prescher, J. A. Developing bioorthogonal probes to span a spectrum of reactivities. _Nat. Rev. Chem._ 4, 476–489 (2020). Article  Google Scholar  * Oliveira, B. L., Guo,


Z. & Bernardes, G. J. L. Inverse electron demand Diels–Alder reactions in chemical biology. _Chem. Soc. Rev._ 46, 4895–4950 (2017). Article  Google Scholar  * Jayasinghe, M. K. et al.


Extracellular vesicle surface display enhances the therapeutic efficacy and safety profile of cancer immunotherapy. _Mol. Ther._ 32, 3558–3579 (2024). Article  Google Scholar  * Miao, Y. et


al. Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery. _Nat. Commun._ 15, 1159 (2024). Article  Google Scholar  Download


references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Chair of Pharmaceutical Biology, Department of Biology, Faculty of Science, Friedrich-Alexander Universität Erlangen-Nürnberg,


Erlangen, Germany Leila Pourtalebi Jahromi & Gregor Fuhrmann * FAU NeW, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany Gregor Fuhrmann Authors * Leila Pourtalebi


Jahromi View author publications You can also search for this author inPubMed Google Scholar * Gregor Fuhrmann View author publications You can also search for this author inPubMed Google


Scholar CORRESPONDING AUTHOR Correspondence to Gregor Fuhrmann. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pourtalebi Jahromi, L., Fuhrmann, G. A chemical toolbox for surface engineering of extracellular vesicles. _Nat Rev Bioeng_ (2025).


https://doi.org/10.1038/s44222-025-00310-9 Download citation * Published: 25 April 2025 * DOI: https://doi.org/10.1038/s44222-025-00310-9 SHARE THIS ARTICLE Anyone you share the following


link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature


SharedIt content-sharing initiative