A nucleic acid detection device for rapid multiplexed molecular disease diagnostics

A user-friendly nucleic acid detection device, called QolorEX, uses plasmonic nanostructures to provide colorimetric readouts with gold-standard-test accuracy for fully automated, deployable

multiplex disease diagnostics. Here, we explore its journey towards commercialization, highlighting its underlying approach and the challenges faced in bringing this technology to the

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Contact customer support REFERENCES * Mahshid, S. S., Flynn, S. E. & Mahshid, S. The potential application of electrochemical biosensors in the COVID-19 pandemic: a perspective on the

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the next pandemic. _Front. Sci._ 2, 1412291 (2024). Article  MATH  Google Scholar  Download references ACKNOWLEDGEMENTS S.G.Y. is a recipient of a Vanier Canada Graduate Scholarship from

the Government of Canada. Beeta Biomehas been supported by awards from McGill Innovation Fund, Clinical Innovation Platform from Montreal General Hospital, and Ministère de l’Économie, de

l’Innovation et de l’Énergie. S.S.M. is the recipient of Mitacs Entrepreneur International awards, 2024. S.M. is a Canada Research Chair in Nano/Biosensing Devices and recipient of the

2022–2024 NSERC Alliance Mission grant, the 2022–2023 William and Rhea Seath Awards in Engineering Innovation, and the 2021–2024 CIHR Emerging COVID-19 Research Gaps and Priorities. T.A. is

a recipient of a FRQNT doctoral fellowship. R.S.M. is a recipient of NSERC Canada Graduate Scholarships–Doctoral. AUTHOR INFORMATION Author notes * These authors contributed equally: Sahar

S. Mahshid, Sripadh Guptha Yedire. AUTHORS AND AFFILIATIONS * Beeta Biomed, Clinical Innovation Platform, Montreal General Hospital, Montreal, Quebec, Canada Sahar S. Mahshid & Roozbeh

S. Moakhar * Department of Bioengineering, McGill University, Montreal, Quebec, Canada Sripadh Guptha Yedire, Roozbeh S. Moakhar, Tamer AbdElFatah & Sara Mahshid * Division of

Experimental Medicine, McGill University, Montreal, Quebec, Canada Sara Mahshid Authors * Sahar S. Mahshid View author publications You can also search for this author inPubMed Google

Scholar * Sripadh Guptha Yedire View author publications You can also search for this author inPubMed Google Scholar * Roozbeh S. Moakhar View author publications You can also search for

this author inPubMed Google Scholar * Tamer AbdElFatah View author publications You can also search for this author inPubMed Google Scholar * Sara Mahshid View author publications You can

also search for this author inPubMed Google Scholar CONTRIBUTIONS S.S.M. and S.G.Y. contributed to the preparation of the initial manuscript draft and subsequent revisions. R.S.M., T.A. and

S.M. revised and proofread the manuscript. S.S.M. and S.M. designed and supervised the project. CORRESPONDING AUTHORS Correspondence to Sahar S. Mahshid or Sara Mahshid. ETHICS DECLARATIONS

COMPETING INTERESTS S.S.M., R.S.M. and S.M. are cofounders of Beeta Biomed, a startup company focused on commercializing nanostructured diagnostic devices and biosensors. ADDITIONAL

INFORMATION RELATED LINKS OTHER HIGH-RISK PATHOGENS: https://www.who.int/emergencies/disease-outbreak-news RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Mahshid, S.S., Yedire, S.G., Moakhar, R.S. _et al._ A nucleic acid detection device for rapid multiplexed molecular disease diagnostics. _Nat Rev Bioeng_ 3, 187–189 (2025).

https://doi.org/10.1038/s44222-025-00288-4 Download citation * Published: 26 February 2025 * Issue Date: March 2025 * DOI: https://doi.org/10.1038/s44222-025-00288-4 SHARE THIS ARTICLE

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