- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
Access through your institution Buy or subscribe Cryo-electron tomography (cryo-ET) provides a powerful tool to image protein structures within living cells. However, visualizing proteins in
the plasma membrane remains challenging. Cryo-ET requires samples to be thinner than 300 nm — approximately 10–100 times thinner than a typical cell. This can be achieved by imaging
naturally thin cellular projections, albeit often at low resolution. Alternatively, cells can be mechanically thinned using focused ion beam milling — a low-throughput technique that
preserves the native biological environment but also yields low resolution. Achieving high-resolution imaging of specific plasma membranes therefore remains challenging. This is a preview of
subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 digital issues and online access to articles $119.00
per year only $9.92 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated
during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Sun, W. W. et al.
Cryo-electron tomography pipeline for plasma membranes. _Nat. Commun._ 16, 855 (2025) Article MATH Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature
Reviews Bioengineering https://www.nature.com/natrevbioeng/ Christine-Maria Horejs Authors * Christine-Maria Horejs View author publications You can also search for this author inPubMed
Google Scholar CORRESPONDING AUTHOR Correspondence to Christine-Maria Horejs. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Horejs, CM. High-resolution
imaging of plasma membrane proteins. _Nat Rev Bioeng_ 3, 192 (2025). https://doi.org/10.1038/s44222-025-00283-9 Download citation * Published: 07 February 2025 * Issue Date: March 2025 *
DOI: https://doi.org/10.1038/s44222-025-00283-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative
