Risk of pots after vaccine versus covid-19 confounded


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Access through your institution Buy or subscribe arising from A.C. Kwan et al. _Nature Cardiovascular Research_ https://doi.org/10.1038/s44161-022-00177-8 (2022) Postural orthostatic


tachycardia syndrome (POTS) may be a sequela of coronavirus disease 2019 (COVID-19). Kwan et al. reported that the risk of POTS was 5.35 times higher after severe acute respiratory syndrome


coronavirus 2 (SARS-CoV-2) infection compared to after COVID-19 vaccination. However, the risk of POTS was 4.69 times higher before SARS-CoV-2 infection compared to before COVID-19


vaccination. Therefore, the SARS-CoV-2-infected and COVID-19-vaccinated populations were not comparable at baseline, and the finding that POTS-associated diagnoses after SARS-CoV-2 infection


were much higher than after COVID-19 vaccination was hopelessly confounded. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your


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subscriptions * Read our FAQs * Contact customer support DATA AVAILABILITY All data used in this Matters Arising are available in ref. 1. REFERENCES * Kwan, A. C. et al. Apparent risks of


postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-CoV-2 infection. _Nat. Cardiovasc. Res._ 1, 1187–1194 (2022). Article  PubMed  PubMed Central  Google


Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada Ari R. Joffe Authors * Ari R. Joffe View


author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS The author (A.R.J.) made all contributions to the conception or design of the work; the


acquisition, analysis and interpretation of data; drafted the work; approved the submitted version; and agreed both to be personally accountable for the author’s own contributions and to


ensure that questions related to the accuracy or integrity of any part of the work are appropriately investigated, resolved and the resolution documented in the literature. CORRESPONDING


AUTHOR Correspondence to Ari R. Joffe. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing interests. PEER REVIEW PEER REVIEW INFORMATION _Nature Cardiovascular


Research_ thanks Jennifer Nicholas for her contribution to the peer review of this work. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional


claims in published maps and institutional affiliations. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Joffe, A.R. Risk of POTS after vaccine versus


COVID-19 confounded. _Nat Cardiovasc Res_ 2, 871–872 (2023). https://doi.org/10.1038/s44161-023-00329-4 Download citation * Received: 22 December 2022 * Accepted: 10 August 2023 * Published:


11 September 2023 * Issue Date: October 2023 * DOI: https://doi.org/10.1038/s44161-023-00329-4 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:


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