Lipid remodeling in megakaryocyte differentiation and platelet biogenesis

Lipid remodeling, from fatty acid transport and de novo lipid synthesis, is necessary for megakaryocyte differentiation and platelet production. Dietary saturated fatty acids, impaired fatty

acid transport and/or dysfunction in lipid biogenesis can contribute to low platelet counts. Access through your institution Buy or subscribe This is a preview of subscription content,

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ACKNOWLEDGEMENTS This work was funded in part by the US National Institutes of Health (R01-HL122815, R01-HL150515 and U54-DK106857) to J.H. and by an American Heart Association Career

Development Award (23CDA1054296) to K.J. AUTHOR INFORMATION Author notes * These authors contributed equally: Kanika Jain, Tarun Tyagi. AUTHORS AND AFFILIATIONS * Yale Cardiovascular

Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA Kanika Jain, Tarun Tyagi & John Hwa * Yale

Cooperative Center of Excellence in Hematology, Yale University School of Medicine, New Haven, CT, USA John Hwa Authors * Kanika Jain View author publications You can also search for this

author inPubMed Google Scholar * Tarun Tyagi View author publications You can also search for this author inPubMed Google Scholar * John Hwa View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to John Hwa. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jain, K., Tyagi, T. & Hwa, J. Lipid remodeling in megakaryocyte differentiation and platelet biogenesis. _Nat

Cardiovasc Res_ 2, 803–804 (2023). https://doi.org/10.1038/s44161-023-00324-9 Download citation * Published: 04 September 2023 * Issue Date: September 2023 * DOI:

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