Unchecked autoreactive cd8+ t cells wreak havoc in cancer immunotherapy

Cytotoxic T cells react to cardiac peptides in patients with cancer that receive immunotherapy, resulting in myocarditis. Identifying the targets for T cells in patients who are

immunosuppressed will enable a better understanding of individual risk before treatment is initiated Access through your institution Buy or subscribe This is a preview of subscription

content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 digital issues and online access to articles $119.00 per year only

$9.92 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout

ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Johnson, D. B. et al. _Nat. Rev. Clin. Oncol._ 19,

254–267 (2022). Article  Google Scholar  * Wang, D. Y. et al. _JAMA Oncol._ 4, 1721–1728 (2018). Article  Google Scholar  * Axelrod, M. L. et al. _Nature_ 611, 818–826 (2022). Article  CAS 

Google Scholar  * Ribas, A. & Wolchok, D. J. _Science_ 359, 1350–1355 (2018). Article  CAS  Google Scholar  * Wei, S. C. et al. _Cancer Discov._ 11, 614–625 (2021). Article  CAS  Google

Scholar  * Johnson, D. B. et al. _New Engl. J. Med._ 375, 1749–1755 (2016). Article  Google Scholar  * Caforio, A. L. P. et al. _Int. J. Cardiol._ 179, 166–177 (2015). Article  Google

Scholar  * Myers, J. M. et al. _JCI Insight_ 1, e85851 (2016). Article  Google Scholar  * Gil-Cruz, C. et al. _Science_ 366, 881–886 (2019). Article  CAS  Google Scholar  * Lv, H. et al. _J.

Clin. Invest._ 121, 1561–1573 (2011). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Toronto General Hospital Research Institute, University

Health Network, Toronto, ON, Canada Anthony Wong & Slava Epelman * Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON, Canada Anthony Wong 

& Slava Epelman * Department of Immunology, University of Toronto, Toronto, ON, Canada Anthony Wong & Slava Epelman * Department of Laboratory Medicine and Pathobiology, University

of Toronto, Toronto, ON, Canada Slava Epelman * Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada Slava Epelman Authors * Anthony Wong View author publications You

can also search for this author inPubMed Google Scholar * Slava Epelman View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to Slava Epelman. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wong, A., Epelman, S. Unchecked autoreactive CD8+ T cells wreak havoc in

cancer immunotherapy. _Nat Cardiovasc Res_ 1, 1111–1113 (2022). https://doi.org/10.1038/s44161-022-00184-9 Download citation * Published: 02 December 2022 * Issue Date: December 2022 * DOI:

https://doi.org/10.1038/s44161-022-00184-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative