An unnoticed player overseeing csf flux

A new study shows that brain-resident parenchymal border macrophages (PBMs) maintain perivascular extracellular matrix composition by the release of matrix metalloproteinases. Depletion of

PBMs suppressed glymphatic fluid transport, underscoring their responsibility for perivascular space homeostasis and brain protein clearance. Access through your institution Buy or subscribe

This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 digital issues and online access

to articles $119.00 per year only $9.92 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes

which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Papadopoulos, Z.,

Herz, J. & Kipnis, J. _J. Immunol._ 204, 286–293 (2020). Article  CAS  Google Scholar  * Karam, M., Janbon, H., Malkinson, G. & Brunet, I. _J. Cereb. Blood Flow Metab._ 42, 1797–1812

(2022). Article  CAS  Google Scholar  * Drieu, A. et al. _Nature_ 611, 585–593 (2022). Article  CAS  Google Scholar  * Mato, M., Ookawara, S. & Kurihara, K. _Am. J. Anat._ 157, 329–332

(1980). Article  CAS  Google Scholar  * Ousman, S. S. & Kubes, P. _Nat. Neurosci._ 15, 1096–1101 (2012). Article  CAS  Google Scholar  * Park, L. et al. _Circ. Res._ 121, 258–269 (2017).

Article  CAS  Google Scholar  * Li, Q. & Barres, B. A. _Nat. Rev. Immunol._ 18, 225–242 (2018). Article  CAS  Google Scholar  * Yunna, C., Mengru, H., Lei, W. & Weidong, C.

Macrophage M1/M2 polarization. _Eur. J. Pharmacol._ 877, 173090 (2020). Article  Google Scholar  * Campbell, R. A., Docherty, M.-H., Ferenbach, D. A. & Mylonas, K. J. _Front. Immunol._

12, 700790 (2021). Article  CAS  Google Scholar  * Clarke, L. E. et al. _Proc. Natl Acad. Sci. USA_ 115, E1896–E1905 (2018). CAS  Google Scholar  * Kress, B. T. et al. _Ann. Neurol._ 76,

845–861 (2014). Article  CAS  Google Scholar  * Hawkes, C. A. & McLaurin, J. _Proc. Natl Acad. Sci. USA_ 106, 1261–1266 (2009). Article  CAS  Google Scholar  * Elkington, P. T., Green,

J. A. & Friedland, J. S. _Methods Mol. Biol._ 531, 253–265 (2009). Article  CAS  Google Scholar  * Thanopoulou, K., Fragkouli, A., Stylianopoulou, F. & Georgopoulos, S. _Proc. Natl

Acad. Sci. USA_ 107, 20816–20821 (2010). Article  CAS  Google Scholar  * Rasmussen, M. K., Mestre, H. & Nedergaard, M. _Lancet Neurol._ 17, 1016–1024 (2018). Article  CAS  Google Scholar

  Download references ACKNOWLEDGEMENTS We thank D. Xue for expert graphical support. This project has received funding from the Simons Foundation, the Dr. Miriam and Sheldon G. Adelson

Medical Research Foundation, the US NIH/NINDS/NCCIH (R01AT012312, R01AT011439 and U19 NS128613) and the Novo Nordisk and Lundbeck Foundations, as well as the US Army Research Office (grant

MURI W911NF1910280). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark Virginia Plá & Maiken Nedergaard

* Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA Maiken Nedergaard Authors * Virginia Plá View author publications You can also search for

this author inPubMed Google Scholar * Maiken Nedergaard View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Virginia

Plá. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Plá, V.,

Nedergaard, M. An unnoticed player overseeing CSF flux. _Nat Cardiovasc Res_ 1, 1114–1115 (2022). https://doi.org/10.1038/s44161-022-00176-9 Download citation * Published: 02 December 2022 *

Issue Date: December 2022 * DOI: https://doi.org/10.1038/s44161-022-00176-9 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link

Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative