Aging stem cells limit tumorigenesis

Access through your institution Buy or subscribe “Previous work using cancer cell line transplantation in young and aged host mice has improved our understanding of changes in the aged host

tumor microenvironment and tumor progression, but these models represent advanced stages of tumor growth with limited insight into the early phase of tumor initiation. This had limited our

understanding of how tumor initiation and early progression are affected by aging,” explains Tuomas Tammela, the study’s corresponding author. To evaluate the effect of aging on the

initiation of tumor growth, Zhuang and colleagues used genetically engineered mouse models to initiate lung cancer in both young (12–16 weeks old, a biological age that corresponds to young

human adults) and aged (104–130 weeks old, corresponding to approximately 70-year-old humans) mice, in which the oncogene _Kras__G12D_ is activated and the p53 tumor suppressor is deleted

selectively in alveolar type II (AT2) stem cells; these cells are known to promote tissue regeneration in response to injury, and can also be responsible for the development of a form of

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AFFILIATIONS * Nature Aging https://www.nature.com/nataging/ Yahyah Aman Authors * Yahyah Aman View author publications You can also search for this author inPubMed Google Scholar

CORRESPONDING AUTHOR Correspondence to Yahyah Aman. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Aman, Y. Aging stem cells limit tumorigenesis. _Nat

Aging_ 5, 10 (2025). https://doi.org/10.1038/s43587-025-00805-5 Download citation * Published: 15 January 2025 * Issue Date: January 2025 * DOI: https://doi.org/10.1038/s43587-025-00805-5

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