Toward phage therapy for tuberculosis


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Access through your institution Buy or subscribe Tuberculosis (TB) is a highly infectious disease caused by _Mycobacterium tuberculosis_ (_Mtb_), which primarily affects the lungs to cause


pulmonary TB, but can also affect other tissues to cause extra-pulmonary TB. _Mtb_ is an intracellular pathogen that can evade the immune system and proliferate within host cells, making


antibiotic treatment more challenging and potentially resulting in antimicrobial resistance. Bacteriophage therapy has emerged as a renewed approach to eliminate bacterial infections, but


the potential of phage therapy for the treatment for _Mtb_ infection requires further investigation. Using humanized mice (NSG-SGM3 mice, transgenically expressing three human


cytokine/chemokine genes) infected with _Mtb_, researchers showed that mice treated with phage DS6A had increased body weight and improved pulmonary function compared to control


_Mtb_-infected mice. Further analysis revealed that DS6A reduced _Mtb_ load in mouse organs with greater efficacy in the spleen, demonstrating the feasibility of developing phage therapy as


a therapeutic strategy against _Mtb_ infection. ORIGINAL REFERENCE: Yang, F. et al. _Commun. Biol_. 7, 294 (2024) This is a preview of subscription content, access via your institution


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AUTHORS AND AFFILIATIONS * Lab Animal http://www.nature.com/laban/ Alexandra Le Bras Authors * Alexandra Le Bras View author publications You can also search for this author inPubMed Google


Scholar CORRESPONDING AUTHOR Correspondence to Alexandra Le Bras. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Le Bras, A. Toward phage therapy for


tuberculosis. _Lab Anim_ 53, 87 (2024). https://doi.org/10.1038/s41684-024-01358-7 Download citation * Published: 03 April 2024 * Issue Date: April 2024 * DOI:


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