Effectiveness of intra-venous steroids for preventing surgery for lumbo-sacral radiculopathy secondary to intervertebral disc herniation: a retrospective study of 213 patients

ABSTRACT The natural history of lumbar disc herniation with radiculopathy is favorable, with 95% of patients expected to be pain-free within 6 months of onset. Despite the favorable

prognosis, operative treatment is often chosen by patients unable to “ride out” the radicular episode. Prospective studies comparing surgical with non-surgical treatment have demonstrated

similar long-term results. We conducted a retrospective case-series study of patients with a lumbar disc herniation and intractable radicular pain without significant neurological deficits

treated with intra-venous dexamethasone. The primary outcome measure was whether the patient had undergone operative treatment within 1 year of receiving the intravenous steroid treatment.

213 patients met our inclusion criteria. 30 were lost to follow-up and 2 had died before completing 1 year of follow-up. Of the remaining 181 patients, 133 (73.48%) had not undergone surgery

within 1 year of receiving intra-venous steroid treatment while 48 (26.51%) had undergone surgery. 6 (3.31%) of the patients had undergone surgery more than 1 year of receiving IV steroid

treatment. Intravenous steroid treatment in our retrospective series was approximately 30% better at preventing the need for surgery than the reported outcomes of conservative treatment in

randomized controlled trials previously published. SIMILAR CONTENT BEING VIEWED BY OTHERS CORRELATION BETWEEN PARAVERTEBRAL SPREAD OF INJECTATE AND CLINICAL EFFICACY IN LUMBAR TRANSFORAMINAL

BLOCK Article Open access 13 July 2020 ASSOCIATION BETWEEN SPINOPELVIC PARAMETERS AND POSTOPERATIVE URINARY RETENTION IN THORACOLUMBAR SPINE SURGERY: A PROPENSITY-MATCHED ANALYSIS Article

Open access 01 June 2025 ENZYMATIC CHEMONUCLEOLYSIS FOR LUMBAR DISC HERNIATION—AN ASSESSMENT OF HISTORICAL AND CONTEMPORARY EFFICACY AND SAFETY: A SYSTEMATIC REVIEW AND META-ANALYSIS Article

Open access 04 June 2024 INTRODUCTION It has been known for many years that acute radicular pain due to lumbar disc herniation carries a favorable prognosis, regardless of treatment1,2,3,4.

Hakelius in 1970, in a retrospective comparison of 583 patients undergoing conservative or surgical treatment, found that 96% of the patients treated surgically and 89% of the patients

treated conservatively, were free of symptoms within 6 months of onset1. Gugliotta et al., in a prospective trial of 370 patients, all potential candidates for surgical treatment and

allocated to surgical or conservative treatment by their treating physicians, found significantly better reduction in radicular pain at 3 weeks in the surgically treated group, but in the 3 

month to 2 year follow-up there was no difference between the groups4. Weinstein et al. in the Spinal Patient Outcomes Research Trials (SPORT), found in 501 patients randomly allocated to

either conservative or surgical treatment in 13 participating centers, no statistically significant difference in all primary outcome measures between the groups for up to 2 years of

follow-up5. The study had a high 1-year crossover rate, with 41% of patients allocated to the surgical treatment group undergoing conservative therapy, and 43% of patients allocated to the

conservative treatment group undergoing surgery. Similar findings and crossover rate were also noted by Peul et al.6. The term ‘disc herniation’ along with the term ‘sciatica’ are used

colloquially to signify leg pain originating from a lumbar spine pathology. While in essence this is correct, many spinal and extra-spinal pathologies can produce similar symptoms, therefore

spine professionals need better terminology enabling diagnosis of a much more specific pathology, for effective treatment to be offered7. Hence, in addition to the spine level, disc

pathology is classified as bulge or herniation or extrusion or sequestration, the location as central, lateral, foraminal or extra-foraminal (“far lateral”) and the sciatica as L3 or L4 or

L5 or S1 radiculopathy8. Only when all of these parameters correlate, an invasive treatment such as lumbar discectomy can be successful7. An erroneous or non-specific diagnosis may lead

almost invariably to sub-optimal surgical outcomes. While surgical treatment for lumbar disc herniation is limited to a few surgical options, the term ‘conservative therapy’ encompasses a

vast array of options, none of them shown to be significantly more effective than another, or provide better short-term outcomes superior to the improvement expected with the passage of time

from onset3,9,10,11. For the researcher seeking to study conservative treatment outcomes, this creates a methodological problem as there is no set benchmark for conservative treatment

success to compare with. An alternative option is to evaluate the number of patients failing conservative treatment, a benchmark clearly set by the crossover rates in previously published

randomized controlled trials2,5,6,10,12, thus making the comparison to the expected failure, clearly defined by opting for surgery. One of the conservative treatment options is

administration of glucocorticoid steroids. These can be delivered either orally, parenterally, intravenously or injected within the spinal structures3,11,13. Goldberg et al. reported

moderate improvement in function and no difference in pain in a randomized prospective trial of 269 patients receiving either oral prednisone or placebo13. Lee et al., in a meta-analysis of

14 high quality randomized controlled trials (RCT’s) pooling 1502 patients receiving either epidural steroids or placebo/local anesthetic/saline, found a statistically significant reduction

in pain, but not in function, at 1 month and 3 months, with a non-significant difference at 6 months for the steroid group14. Aminmansour et al. reported a significant reduction in

postoperative radicular pain in patients receiving intravenous 40/ 80 mg dexamethasone intraoperatively vs. placebo in an RCT of 61 patients15. Finckh et al. in a study of 65 patients

randomized to receive either IV 500 mg methylprednisolone or placebo found a significant difference of small magnitude in the reduction of leg pain in the steroid group during the first 3 

days, but this effect did not persist16. The optimal end result of conservative therapy is complete resolution of symptoms without the need for surgery in a time-frame acceptable to the

patient. Unfortunately, there is no universal agreement as to what this time-frame is, with recommendations for surgery ranging from 6 weeks to 12 months from symptom onset11,17. Our spine

unit is located in a 722 bed regional referral hospital, serving a population of approximately 650,000. It is common practice for family physicians and community orthopedic surgeons to refer

to our emergency room patients with intractable radiculopathy due to an established lumbar disc herniation that have failed conservative ambulatory treatment. Most are rapidly discharged

after receiving analgesic therapy, and patients with severe or progressive neurological symptoms are operated on an emergent basis, but patients without significant neurological deficits,

unable to be discharged from the emergency room, are hospitalized for IV steroid therapy as part of our usual treatment protocol. Having intractable pain and failing ambulatory conservative

treatment essentially means that all of this patient subset consists of potential surgical candidates, meeting similar inclusion criteriae to the patients randomized in previous studies

comparing conservative to surgical treatment2,4,5,10,18. The aim of this study was to determine the percentage of patients opting for surgical treatment within 1 year of receiving IV

steroids for lumbar radiculopathy secondary to a disc herniation and compare the group that eventually underwent surgery with the group that did not. MATERIALS AND METHODS This was a

retrospective cohort study utilizing data retrieved from our hospital’s electronic database and a telephone survey. To achieve a power of 80% (Based on 2-tailed Independent sample t-test,

Alpha = 5%, effect size 0.2), a minimum of 160 patients were needed, calculated using the Gpower software19. Included were all patients aged 18 and over, admitted to our spine surgery unit

between August 2014 and January 2018 for treatment of intractable lumbar radicular pain clinically corresponding to a disc herniation or extrusion demonstrated on recent imaging (level,

location and side-matched pain). Excluded were patients discharged without completing the IV steroid course for any reason other than having surgery or patients that were retrospectively

found to have had another underlying concurrent pathology producing the radicular clinical symptoms. All patients received a single daily IV dexamethasone (Dexacort forte, Teva,

Israel/Hungary) 1 mg/kg up to a daily maximum of 60 mg for six consecutive days. The dosage was tapered as follows: 100% on the first and second days, 50% on the third and fourth days, 25%

on the fifth and sixth days, and then discontinued. IV proton pump inhibitors or H2 receptor antagonists were given throughout the duration of the steroid therapy, and additional analgesics

(acetaminophen and/or dipyrone and/or tramadol or narcotics) provided if asked for pro re nata (p.r.n). Non-steroidal anti inflammatory drugs (NSAIDS) were not given due to the possibility

of synergic erosive gastritis with concurrent high-dose steroids. All patients included in the study were reviewed to determine if they had undergone surgery within 1 year of receiving IV

steroid therapy. If their electronic records did not indicate they had been operated at our hospital, they were contacted by telephone and asked by if they had undergone surgery for their

lumbar radiculopathy elsewhere. Statistical analysis was performed using IBM SPSS Statistics software version 25. Quantitative data was presented as mean ± SD, median and range. Qualitative

data was presented as frequencies and percentages. Quantitative data was compared between the groups using the Independent t-test or Mann–Whitney test, according to variable distribution. If

the normality assumption was violated we chose the Mann–Whitney test. Qualitative data was compared with the Chi square test or Fisher's exact tests (if expectancy was < 5). All

tests performed and all reported values were two-sided unless otherwise indicated. A p value less or equal to 0.05 was considered significant. ETHICAL APPROVAL This study was conducted

according to the principles of the declaration of Helsinki and approved by the Galilee Medical Center medical ethics review board (0010-18-NHR, Israel ministry of health registration

20182062). CONSENT TO PARTICIPATE A full waiver of informed consent was approved by the Galilee Medical Center medical ethics review board (0010-18-NHR, Israel ministry of health

registration 20182062) Since it was done retrospectively on unidentified data obtained from patient medical records. All patients contacted by phone were informed as to the nature of the

study and gave their consent to participate. CONSENT FOR PUBLICATION Only anonymous patient data is reported, therefore no consent for publication was required. RESULTS 213 consecutive

patients answering our inclusion criteria were found. 30 were not reviewed because they were lost to follow-up and/or did not have updated contact details. 2 patients, who had not undergone

surgery, died within the 1 year post-treatment duration and were therefore excluded as well (see Table 1, detailed study flow diagram). Of the remaining 181 patients, 133 (73.48%) had not

undergone surgery within 1 year of receiving IV steroid treatment (the primary outcome measure), 48 (26.51%) had undergone surgery. 6 (3.31%) of the patients had undergone surgery more than

1 year of receiving IV steroid treatment. No significant difference was found in the mean age, gender or comorbidities between the two groups (Tables 2,3). DISCUSSION The definition of

treatment success or failure in a time-dependent self-resolving medical condition is difficult. As any treatment for radicular pain without neurological deficits must provide results that

are better than the well-established excellent natural history20, the proposed therapy is expected to either shorten the clinical course and/or lower pain levels and/or produce better long

term outcomes than other therapies. Many outcome measures have been utilized to evaluate treatment success in previous studies, such as the length of the radicular episode, self-reported

pain levels, return to work rate, physical and mental questionnaires, overall patient satisfaction and more1,2,5,9,10,11,14,21. While most of these measures are validated and comparable, it

is difficult to set a clear value defining unequivocal success. Another problem in evaluating the efficacy of radicular pain treatment is determining the denominator, since a substantial

number of radicular episodes, probably most, will resolve before reaching the spine specialist who can suggest a surgical option22. It is therefore difficult to determine from what

percentage of patients “over the radar” the treatment and control groups should be selected and success or failure decided. To overcome this problem, we have defined all patients referred to

our emergency department for treatment of intractable radicular pain as the denominator, seeing all of them as fulfilling the North American Spine Society (NASS) criteria for surgical

treatment11, since they had already failed conservative therapy. Determining the numerator is no less difficult as there is no agreed expected percentage of success or failure of

conservative treatment. We have chosen the cross-over numbers reported in randomized controlled trials (RCT), as the numerator benchmark. Weinstein et al. in the SPORT trial5 found that 43%

of the patients assigned to conservative care, crossed over and had surgery within 12 months, and that 59% of the patients randomized for surgical treatment underwent surgery by 12 months of

randomization. Peul et al.12 in a similar study, found that 44% of patients randomized to conservative care had surgery eventually, the vast majority within 1 year. Since their selection

criteria was generally similar to ours, all of our patients could be considered potential candidates for randomization in those trials, and the 43–44% cross-over rate could generate the

expected numerator. We have found that only 26.51% of our patient cohort had undergone surgery within 1 year and an additional 3.31% had surgery later than 1 year after IV steroid treatment.

These numbers are approximately 30% lower than the expected 43–44%, making the 13% difference the possible treatment effect. While we have no definite answer as to why IV steroid therapy in

our series produced superior results when compared to other forms of conservative therapy, several speculations can be made. Extruded intervertebral discs have been shown to leak

proinflammatory cytokines TNF, IL‑1α, IL‑1β, IL‑6 and IL‑17 which contribute to the spinal nerve root irritation inducing radiculopathy23. As steroids have a potent anti-inflammatory effect,

our 6 day long IV steroid protocol might induce a better local reduction of inflammation and/or secondary edema at the affected nerve root site than other forms of administration

(IM/PO/epidural) which are given at lower doses and shorter durations. Another possible explanation might be the simple passage of time. Acute radiculopathy is generally time-limited,

regardless of treatment, but having intractable pain is a strong motivator for surgery in patients unable or unwilling to “ride it out”. If, instead of surgery, 6 days of hospitalization for

analgesic treatment are offered, the radicular episode might be on the decline in some of the patients, enabling them to continue ambulatory conservative care. Our study has several

limitations. This is a single-center study and results might not be the same in other populations. Another limitation is possibly a selection bias, since having intractable acute pain can be

associated with depression, anxiety and mood disorders causing poor coping rather than objective disability24. In this context, glucocorticoids might act by reducing anxiety through a

central mechanism25. We have not utilized any of the personality questionnaires, and therefore cannot state whether this is the case or not. Another limitation is that this study was only

aimed at evaluating the percentage of patients opting for surgery, and did not assess the functional outcome for comparison with other conservative treatment options or with surgical

treatment. As this was a retrospective study of normal clinical practice in our department and not a prospective trial, only the steroid protocol was uniform and additional analgetic

treatment was not uniform. This might lead to concerns that the additional analgesia and not the steroids was responsible for the effect. As current North American Spine Society guidelines

have not found sufficient evidence in favor of any pharmacological intervention over another11 in the treatment of lumbar radiculopathy, we assume, with caution, these variations did not

have any effect on the rate of surgery within 1 year—the main treatment outcome. In conclusion, we have found that high-dose IV steroids are an effective treatment for acute radicular pain,

reducing by 30% the number of patients undergoing surgery within 1 year when compared to data from previously published RCT’s. Further studies are needed to determine the mechanism of this

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Scholar  Download references FUNDING No funding was received in relation to this study. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Bar-Ilan University Medical School, Tzfat, Israel Daniel

Kovarsky & Nimrod Rahamimov * Department of Orthopedics B and Spine Surgery, Galilee Medical Center, Nahariya, Israel Adi Shani, Alon Rod, Dan Ciubotaru & Nimrod Rahamimov Authors *

Daniel Kovarsky View author publications You can also search for this author inPubMed Google Scholar * Adi Shani View author publications You can also search for this author inPubMed Google

Scholar * Alon Rod View author publications You can also search for this author inPubMed Google Scholar * Dan Ciubotaru View author publications You can also search for this author inPubMed

 Google Scholar * Nimrod Rahamimov View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS D.K.: study design, collection of data from electronic

health records and statistical analysis. A.S.: conception of the study and design, critical review. A.R.: collection of data and critical review. D.C.: collection of data and critical

review. N.R.: conceived study and design, wrote the manuscript. CORRESPONDING AUTHOR Correspondence to Nimrod Rahamimov. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

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ARTICLE Kovarsky, D., Shani, A., Rod, A. _et al._ Effectiveness of intra-venous steroids for preventing surgery for lumbo-sacral radiculopathy secondary to intervertebral disc herniation: a

retrospective study of 213 patients. _Sci Rep_ 12, 6681 (2022). https://doi.org/10.1038/s41598-022-10659-1 Download citation * Received: 29 September 2021 * Accepted: 31 March 2022 *

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