The great escape — how inorganic phosphate is released from actin filaments

The release of inorganic phosphate (Pi) from actin marks old actin filaments for disassembly. By combining cryo-electron microscopy (cryo-EM) with in vitro reconstitution and molecular

dynamics simulations, we show how actin filaments release Pi through a ‘molecular backdoor’ and demonstrate that this arrangement is distorted in a disease-linked actin variant. Access

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are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Merino, F., Pospich, S.

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DYNAMIC CELLULAR ACTIN NETWORKS. Article  CAS  PubMed  Google Scholar  Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to

jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Oosterheert, W. et al. Molecular mechanisms of inorganic-phosphate release from the core and

barbed end of actin filaments. _Nat. Struct. Mol. Biol_. https://doi.org/10.1038/s41594-023-01101-9 (2023). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE The great escape — how inorganic phosphate is released from actin filaments. _Nat Struct Mol Biol_ 30, 1621–1622 (2023). https://doi.org/10.1038/s41594-023-01102-8 Download citation

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