Functional epigenomics: chromatin complexity untangled

The development of an epigenetics-focused, CRISPR-based high-content functional genomics screening platform provides insight into chromatin regulation and uncovers a potential strategy to

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support REFERENCES * Bock, C. et al. _Nat. Rev. Methods Primers_ 2, 8 (2022). Article  CAS  Google Scholar  * Dawson, M. A. & Kouzarides, T. _Cell_ 150, 12–27 (2012). Article  CAS 

PubMed  Google Scholar  * Zhao, S., Allis, C. D. & Wang, G. G. _Nat. Rev. Cancer_ 21, 413–430 (2021). Article  PubMed  PubMed Central  Google Scholar  * Gilan, O. et al. _Nat. Struct.

Mol. Biol_. https://doi.org/10.1038/s41594-023-01087-4 (2023). * Husmann, D. & Gozani, O. _Nat. Struct. Mol. Biol._ 26, 880–889 (2019). Article  CAS  PubMed  PubMed Central  Google

Scholar  * Klein, D. C. & Hainer, S. J. _Chromosome Res._ 28, 69–85 (2020). Article  CAS  PubMed  Google Scholar  * Shilatifard, A. _Annu. Rev. Biochem._ 81, 65–95 (2012). Article  CAS 

PubMed  PubMed Central  Google Scholar  * Krivtsov, A. V., Hoshii, T. & Armstrong, S. A. _Cold Spring Harb. Perspect. Med._ 7, a026658 (2017). Article  PubMed  PubMed Central  Google

Scholar  * Bewersdorf, J. P. & Abdel-Wahab, O. _Genes Dev._ 36, 259–277 (2022). Article  CAS  PubMed  PubMed Central  Google Scholar  * Henikoff, S., Henikoff, J. G. & Ahmad, K.

_Bio. Protoc._ 11, e4043 (2021). CAS  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported in part by grants from the US National Institutes

of Health to O.G. (R35 GM139569 and R01 CA278940) and R.M. (T32 CA009302). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biology, Stanford University, Stanford, CA, USA Ricardo

Mack & Or Gozani Authors * Ricardo Mack View author publications You can also search for this author inPubMed Google Scholar * Or Gozani View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Or Gozani. ETHICS DECLARATIONS COMPETING INTERESTS O.G. is a scientific co-founder and stockholder of EpiCypher,

Inc., K36 Therapeutics, Inc. and Alternative Bio, Inc. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mack, R., Gozani, O. Functional epigenomics:

chromatin complexity untangled. _Nat Struct Mol Biol_ 30, 1403–1405 (2023). https://doi.org/10.1038/s41594-023-01088-3 Download citation * Published: 08 September 2023 * Issue Date: October

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