How K helps quickly | Nature Neuroscience


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Access through your institution Buy or subscribe _Nat. Commun_. 13, 2650 (2022) Most antidepressant medications require several weeks to take effect, but ketamine ameliorates depressive


symptoms within hours. The mechanisms that underlie ketamine’s rapid antidepressant effect remain unclear. Rawat et al. provide evidence that, in mice, this effect is mediated by immature


adult-born granule cells in the hippocampus. Using immunohistochemistry, the authors found that a single low dose of ketamine caused an increase in the number of activated immature


adult-born granule cells within 24 h, which matched the timing of the drug’s antidepressant behavioral effects in assays of social interaction, social novelty, and learned helplessness. To


test whether the immature granule cells mediated ketamine’s behavioral effects, the authors silenced these neurons by combining a transgenic mouse model with chemogenetics. This intervention


completely prevented the acute behavioral effects of ketamine in both naive and chronically stressed mice. Conversely, chemogenetic activation of immature granule cells produced the same


behavioral effects as ketamine. This work identifies a new cellular target for future refinement of antidepressants, and may further invigorate the ongoing discussion about the presence of


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AFFILIATIONS * Nature Neuroscience https://www.nature.com/neuro Charlotte Arlt Authors * Charlotte Arlt View author publications You can also search for this author inPubMed Google Scholar


CORRESPONDING AUTHOR Correspondence to Charlotte Arlt. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Arlt, C. How K helps quickly. _Nat Neurosci_ 25,


677 (2022). https://doi.org/10.1038/s41593-022-01098-2 Download citation * Published: 07 June 2022 * Issue Date: June 2022 * DOI: https://doi.org/10.1038/s41593-022-01098-2 SHARE THIS


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