Metformin action through the microbiome and bile acids

Metformin functions through a gut microbiome–bile acid–farnesoid X receptor axis to lower glucose in type 2 diabetes, revealing a new therapeutic target in this disease. Access through your

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Sterne, J. _Maroc Med._ 36, 1295–1296

(1957). Google Scholar  * Karlsson, F. H. et al. _Nature_ 498, 99 (2013). Article  CAS  PubMed  Google Scholar  * Napolitano, A. et al. _PLoS ONE_ 9, e100778 (2014). Article  PubMed  CAS 

PubMed Central  Google Scholar  * Sun, L. et al. _Nat. Med._ https://doi.org/10.1038/s41591-018-0222-4 (2018). * Chow, M. D., Lee, Y.-H. & Guo, G. L. _Mol. Aspects Med._ 56, 34–44

(2017). Article  CAS  PubMed  PubMed Central  Google Scholar  * Chiang, J. Y. L. et al. _Dig. Dis._ 35, 241–245 (2017). Article  CAS  PubMed  Google Scholar  * Foretz, M. et al. _J. Clin.

Invest._ 120, 2355–2369 (2010). Article  CAS  PubMed  PubMed Central  Google Scholar  * Mueller, M. et al. _J. Hepatol._ 62, 1398–1404 (2015). Article  CAS  PubMed  PubMed Central  Google

Scholar  * Lindor, K. D. et al. _Hepatology_ 39, 770–778 (2004). Article  CAS  PubMed  Google Scholar  * Fang, S. et al. _Nat. Med._ 21, 159–165 (2015). Article  CAS  PubMed  PubMed Central

  Google Scholar  * Pathak, P. et al. _Hepatology_ 68, 1574–1588 (2018). Article  CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA Grace L. Guo * Environmental and Occupational Health Sciences Institute, Rutgers, State

University of New Jersey, Piscataway, NJ, USA Grace L. Guo * VA New Jersey Health Care System, Veterans Administration Medical Center, East Orange, NJ, USA Grace L. Guo * Center for

Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA Wen Xie * Department of Pharmacology and Chemical Biology, University of Pittsburgh,

Pittsburgh, PA, USA Wen Xie Authors * Grace L. Guo View author publications You can also search for this author inPubMed Google Scholar * Wen Xie View author publications You can also

search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Grace L. Guo. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Guo, G.L., Xie, W. Metformin action through the microbiome and bile acids. _Nat Med_ 24, 1789–1790 (2018).

https://doi.org/10.1038/s41591-018-0273-6 Download citation * Published: 06 December 2018 * Issue Date: December 2018 * DOI: https://doi.org/10.1038/s41591-018-0273-6 SHARE THIS ARTICLE

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